ArticleCerebral cortex (New York, N.Y. : 1991)2021
Age-Related Compensatory Reconfiguration of PFC Connections during Episodic Memory Retrieval.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Brain connectivity changes associated with episodic recollection decline in aging: A review of fMRI studies.Frontiers in aging neuroscience · 2022Pooled it
- Multiscale network reorganization during the multidimensional recollection of naturalistic events.Brain structure & function · 2026Article
- Neurovariability as a signature of adaptive brain function.Brain structure & function · 2026Review
- Influence of individual's age on the characteristics of brain effective connectivity.GeroScience · 2025Article
- Computational memory capacity predicts aging and cognitive decline.Nature communications · 2025Article
- Superiority illusion in older adults: Volume and functional connectivity of the precuneus.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Effect of medication on the rostrolateral prefrontal oxygenation and thalamic volume asymmetry in youths with ADHD.Frontiers in integrative neuroscience · 2025Article
- The Impact of Ageing on Episodic Memory Retrieval: How Valence Influences Neural Functional Connectivity.NeuroSci · 2024Article
- Connectivity analyses for task-based fMRI.Physics of life reviews · 2024Review
- Cortical activation in elderly patients with Alzheimer's disease dementia during working memory tasks: a multichannel fNIRS study.Frontiers in aging neuroscience · 2024Article
- Age-related decline in social interaction is associated with decreasedAging brain · 2024Article
- Structural and functional connectivity alteration patterns of the cingulate gyrus in Type 2 diabetes.Annals of clinical and translational neurology · 2023Article
- Age-related reorganization of functional network architecture in semantic cognition.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Cooperation and competition between the default mode network and frontal parietal network in the elderly.Frontiers in psychology · 2023Article
- Whole-brain connectivity during encoding: age-related differences and associations with cognitive and brain structural decline.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Longitudinal resting-state functional connectivity and regional brain atrophy-based biomarkers of preclinical cognitive impairment in healthy old adults.Aging clinical and experimental research · 2022Article
- Age-related dedifferentiation and hyperdifferentiation of perceptual and mnemonic representations.Neurobiology of aging · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
During demanding cognitive tasks, older adults (OAs) frequently show greater prefrontal cortex (PFC) activity than younger adults (YAs). This age-related increase in PFC activity is often associated with enhanced cognitive performance, suggesting functional compensation. However, the brain is a complex network of interconnected regions, and it is unclear how network connectivity of PFC regions differs for OAs versus YAs. To investigate this, we examined the age-related difference on the functional brain networks mediating episodic memory retrieval. YAs and OAs participants encoded and recalled visual scenes, and age-related differences in network topology during memory retrieval were investigated as a function of memory performance. We measured both changes in functional integration and reconfiguration in connectivity patterns. The study yielded three main findings. First, PFC regions were more functionally integrated with the rest of the brain network in OAs. Critically, this age-related increase in PFC integration was associated with better retrieval performance. Second, PFC regions showed stronger performance-related reconfiguration of connectivity patterns in OAs. Finally, the PFC reconfiguration increases in OAs tracked reconfiguration reductions in the medial temporal lobe (MTL)-a core episodic memory region, suggesting that PFC connectivity in OAs may be compensating for MTL deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.