Evidence map›Paper›PMID 32709986›Full record

ArticleScientific reports2020

Increased mitochondrial respiration of adipocytes from metabolically unhealthy obese compared to healthy obese individuals.

Anja Böhm, Michaela Keuper, Tobias Meile, Marty Zdichavsky, Andreas Fritsche, Hans-Ulrich Häring, Martin Hrabě de Angelis, Harald Staiger, Andras Franko

Open access · goldAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 50 citations in OpenAlex.

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  18. Store-operated CaPNAS nexus · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Anja BöhmDepartment of Internal Medicine IV, Division of Endocrinology, Diabetology, Nephrology, University Hospital Tübingen, Eberhard Karls University Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany. anja.moller@med.uni-tuebingen.de.
Michaela KeuperInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich At the Eberhard Karls University Tübingen, Tübingen, Germany.
Tobias MeileClinic for General, Visceral, Thoracic and Transplant Surgery, Klinikum Stuttgart, Bad Cannstatt, Germany.
Marty ZdichavskyDepartment of General, Visceral and Transplant Surgery, University Hospital, Eberhard Karls University Tübingen, Tübingen, Germany.
Andreas FritscheDepartment of Internal Medicine IV, Division of Endocrinology, Diabetology, Nephrology, University Hospital Tübingen, Eberhard Karls University Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.
Hans-Ulrich HäringDepartment of Internal Medicine IV, Division of Endocrinology, Diabetology, Nephrology, University Hospital Tübingen, Eberhard Karls University Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.
Martin Hrabě de AngelisGerman Center for Diabetes Research (Deutsches Zentrum für Diabetesforschung, DZD), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-7898-2353
Harald StaigerGerman Center for Diabetes Research (Deutsches Zentrum für Diabetesforschung, DZD), Neuherberg, Germany.
Andras FrankoDepartment of Internal Medicine IV, Division of Endocrinology, Diabetology, Nephrology, University Hospital Tübingen, Eberhard Karls University Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.ORCID http://orcid.org/0000-0003-0485-5439
Deutsches Diabetes-Zentrum e.V. · DEBG Klinik Tübingen · DEHelmholtz Zentrum München · DEKlinikum Stuttgart · DEStockholm University · SEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among obese subjects, metabolically healthy (MHO) and unhealthy obese (MUHO) subjects exist, the latter being characterized by whole-body insulin resistance, hepatic steatosis, and subclinical inflammation. Insulin resistance and obesity are known to associate with alterations in mitochondrial density, morphology, and function. Therefore, we assessed mitochondrial function in human subcutaneous preadipocytes as well as in differentiated adipocytes derived from well-matched donors. Primary subcutaneous preadipocytes from 4 insulin-resistant (MUHO) versus 4 insulin-sensitive (MHO), non-diabetic, morbidly obese Caucasians (BMI > 40 kg/m

Indexed as

HealthAdipocytesAdultBody Mass IndexCell RespirationFemaleGlycolysisHumansMaleMiddle AgedMitochondriaObesityPhenotype

Identifiers

PMID32709986
PMCPMC7382448
OpenAlexW3044164734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.