Evidence map›Paper›PMID 32709981›Full record

ArticleScientific reports2020

Polymorphism at rs9264942 is associated with HLA-C expression and inflammatory bowel disease in the Japanese.

Hiroshi Suzuki, Satoru Joshita, Atsuhiro Hirayama, Akihiro Shinji, Kenji Mukawa, Minako Sako, Naoki Yoshimura, Tomoaki Suga, Takeji Umemura, Norihiro Ashihara and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Hiroshi SuzukiDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Satoru JoshitaDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. joshita@shinshu-u.ac.jp.
Atsuhiro HirayamaDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Akihiro ShinjiDepartment of Medical Oncology, Japanese Red Cross Society Suwa Red Cross Hospital, Suwa, Japan.
Kenji MukawaDepartment of Gastroenterology, Japanese Red Cross Society Suwa Red Cross Hospital, Suwa, Japan.
Minako SakoCenter for Inflammatory Bowel Disease, Tokyo Yamate Medical Center, Tokyo, Japan.
Naoki YoshimuraCenter for Inflammatory Bowel Disease, Tokyo Yamate Medical Center, Tokyo, Japan.
Tomoaki SugaDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Takeji UmemuraDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Norihiro AshiharaDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Tomoo YamazakiDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Masao OtaDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Shinshu University · JPSuwa Red Cross Hospital · JPTokyo Yamate Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An expression quantitative trait locus (eQTL) single-nucleotide polymorphism (SNP) at rs9264942 was earlier associated with human leukocyte antigen (HLA)-C expression in Europeans. HLA-C has also been related to inflammatory bowel disease (IBD) risk in the Japanese. This study examined whether an eQTL SNP at rs9264942 could regulate HLA-C expression and whether four SNP haplotypes, including the eQTL SNP at rs9264942 and three SNPs at rs2270191, rs3132550, and rs6915986 of IBD risk carried in the HLA-C*12:02~B*52:01~DRB1*15:02 allele, were associated with IBD in the Japanese. HLA-C expression on CD3e

Indexed as

Quantitative Trait LociAdolescentAdultAgedAged, 80 and overCase-Control StudiesColitis, UlcerativeCrohn DiseaseFemaleGene Expression RegulationGenetic Predisposition to DiseaseHaplotypesHealthy VolunteersHLA-C AntigensHumansJapanHLA-C Antigens

Identifiers

PMID32709981
PMCPMC7381613
OpenAlexW3044130804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.