ArticleThe ISME journal2020
Exploring the upper pH limits of nitrite oxidation: diversity, ecophysiology, and adaptive traits of haloalkalitolerant Nitrospira.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Niche specialization and prevalence of comammox Nitrospira in the alkaline sediments of thermokarst lakes on the Tibetan Plateau.Nature communications · 2026Article
- Cultivation-Based Detection of a Novel High-GC Nitrospira Derived From the Argentinian Copahue Volcano Area.Environmental microbiology · 2026Article
- Unique characteristics of acid-tolerant comammox bacteria revealed by multi-omics analyses.ISME communications · 2026Article
- Mechanism of Waterbird Diversity Succession and Its Contribution to Nutrient Loads in Chagan Lake, China.Ecology and evolution · 2025Article
- Sulfur Cycling and Life Strategies in Successional Biocrusts Link to Biomass Carbon in Dryland Ecosystems.Microorganisms · 2025Article
- Genomics and physiological characterizations of an acidotolerant nitrite-oxidizingApplied and environmental microbiology · 2025Article
- Community Structure, Assembly and Interactions ofMicroorganisms · 2025Article
- Development of a nitrifying bacterial community for a low temperature recirculating aquaculture system.World journal of microbiology & biotechnology · 2025Article
- Comparative genome analysis reveals broad phylogenetic and functional diversity within the order Nitrospirales.The ISME journal · 2025Article
- Acid tolerance and metabolic potential of comammox and nitrite-oxidizingISME communications · 2025Article
- Parent soil type modulates biochar and mowing effects on soil microbial communities in karst region.Frontiers in microbiology · 2025Article
- Unveiling unique microbial nitrogen cycling and nitrification driver in coastal Antarctica.Nature communications · 2024Article
- An abundant bacterial phylum with nitrite-oxidizing potential in oligotrophic marine sediments.Communications biology · 2024Article
- Differential effects of winter cold stress on soil bacterial communities, metabolites, and physicochemical properties in two varieties ofMicrobiology spectrum · 2024Article
- Cultivation and genomic characterization of novel and ubiquitous marine nitrite-oxidizing bacteria from the Nitrospirales.The ISME journal · 2023Article
- Nitrification in acidic and alkaline environments.Essays in biochemistry · 2023Review
- Article
- Rapid nitrification involving comammox and canonical Nitrospira at extreme pH in saline-alkaline lakes.Environmental microbiology · 2023Article
- Role of plant metabolites in the formation of bacterial communities in the rhizosphere ofFrontiers in microbiology · 2023Article
- Integrating Genome-Resolved Metagenomics with Trait-Based Process Modeling to Determine Biokinetics of Distinct Nitrifying Communities within Activated Sludge.Environmental science & technology · 2022Article
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12 authors.
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Abstract
Nitrite-oxidizing bacteria of the genus Nitrospira are key players of the biogeochemical nitrogen cycle. However, little is known about their occurrence and survival strategies in extreme pH environments. Here, we report on the discovery of physiologically versatile, haloalkalitolerant Nitrospira that drive nitrite oxidation at exceptionally high pH. Nitrospira distribution, diversity, and ecophysiology were studied in hypo- and subsaline (1.3-12.8 g salt/l), highly alkaline (pH 8.9-10.3) lakes by amplicon sequencing, metagenomics, and cultivation-based approaches. Surprisingly, not only were Nitrospira populations detected, but they were also considerably diverse with presence of members from Nitrospira lineages I, II and IV. Furthermore, the ability of Nitrospira enrichment cultures to oxidize nitrite at neutral to highly alkaline pH of 10.5 was demonstrated. Metagenomic analysis of a newly enriched Nitrospira lineage IV species, "Candidatus Nitrospira alkalitolerans", revealed numerous adaptive features of this organism to its extreme environment. Among them were a sodium-dependent N-type ATPase and NADH:quinone oxidoreductase next to the proton-driven forms usually found in Nitrospira. Other functions aid in pH and cation homeostasis and osmotic stress defense. "Ca. Nitrospira alkalitolerans" also possesses group 2a and 3b [NiFe] hydrogenases, suggesting it can use hydrogen as alternative energy source. These results reveal how Nitrospira cope with strongly fluctuating pH and salinity conditions and expand our knowledge of nitrogen cycling in extreme habitats.
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