ArticleScientific reports2020
The potential for a CRISPR gene drive to eradicate or suppress globally invasive social wasps.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Harnessing CRISPR-Cas technology for insect pest control: current advances and future perspectives.Molecular biology reports · 2026Review
- Article
- Assessing target genes for homing suppression gene drive.The EMBO journal · 2026Article
- Evo-devo and the Biodiversity Crisis.Results and problems in cell differentiation · 2026Article
- Why just fly?Fly · 2025Review
- Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management.Life (Basel, Switzerland) · 2025Review
- Chromosome Structural Rearrangements in Invasive Haplodiploid Ambrosia Beetles Revealed by the Genomes of Euwallacea fornicatus (Eichhoff) and Euwallacea similis (Ferrari) (Coleoptera, Curculionidae, Scolytinae).Genome biology and evolution · 2024Article
- Genes drive organisms and slippery slopes.Pathogens and global health · 2024Review
- Integrated de novo transcriptome of Culex pipiens mosquito larvae as a resource for genetic control strategies.Scientific data · 2024Article
- Unveiling the Genetic Symphony: Harnessing CRISPR-Cas Genome Editing for Effective Insect Pest Management.Plants (Basel, Switzerland) · 2023Review
- Putative target sites in synganglion for novel ixodid tick control strategies.Ticks and tick-borne diseases · 2023Review
- The suppressive potential of a gene drive in populations of invasive social wasps is currently limited.Scientific reports · 2023Article
- Invasion potential of hornets (Hymenoptera: Vespidae:Frontiers in insect science · 2023Review
- Modelling homing suppression gene drive in haplodiploid organisms.Proceedings. Biological sciences · 2022Article
- Gene drive and RNAi technologies: a bio-cultural review of next-generation tools for pest wasp management in New Zealand.Journal of the Royal Society of New Zealand · 2022Article
- Demystifying the Risk Assessment Process for Laboratory-Based Experiments Utilizing Invasive Genetic Elements: It Is More Than Gene Drive.Applied biosafety : journal of the American Biological Safety Association · 2021Article
- Article
- Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives.EFSA journal. European Food Safety Authority · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CRISPR gene drives have potential for widespread and cost-efficient pest control, but are highly controversial. We examined a potential gene drive targeting spermatogenesis to control the invasive common wasp (Vespula vulgaris) in New Zealand. Vespula wasps are haplodiploid. Their life cycle makes gene drive production challenging, as nests are initiated by single fertilized queens in spring followed by several cohorts of sterile female workers and the production of reproductives in autumn. We show that different spermatogenesis genes have different levels of variation between introduced and native ranges, enabling a potential 'precision drive' that could target the reduced genetic diversity and genotypes within the invaded range. In vitro testing showed guide-RNA target specificity and efficacy that was dependent on the gene target within Vespula, but no cross-reactivity in other Hymenoptera. Mathematical modelling incorporating the genetic and life history traits of Vespula wasps identified characteristics for a male sterility drive to achieve population control. There was a trade-off between drive infiltration and impact: a drive causing complete male sterility would not spread, while partial sterility could be effective in limiting population size if the homing rate is high. Our results indicate that gene drives may offer viable suppression for wasps and other haplodiploid pests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.