Evidence map›Paper›PMID 32709888›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2020

RETRACTED: Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis

Johan Linders, Raed Madhi, Milladur Rahman, Matthias Mörgelin, Sara Regner, Max Brenner, Ping Wang, Henrik Thorlacius

RetractedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  12. TREM-1 Modulation Strategies for Sepsis.Frontiers in immunology · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Release mechanisms of major DAMPs.Apoptosis : an international journal on programmed cell death · 2021
    Review
  18. Article
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Johan LindersDepartment of Surgery, Clinical Sciences, Malmö, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden.
Raed MadhiDepartment of Surgery, Clinical Sciences, Malmö, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden.ORCID 0000-0001-7034-646X
Milladur RahmanDepartment of Surgery, Clinical Sciences, Malmö, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden.ORCID 0000-0002-8883-4848
Matthias MörgelinColzyx, Medicon Village, 223 81, Lund, Sweden.
Sara RegnerDepartment of Surgery, Clinical Sciences, Malmö, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden.
Max BrennerCenter for Immunology and Inflammation, The Feinstein Institute for Medical Research, Manhasset, NY, USA.ORCID 0000-0002-8010-148X
Ping WangCenter for Immunology and Inflammation, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
Henrik ThorlaciusDepartment of Surgery, Clinical Sciences, Malmö, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden. henrik.thorlacius@med.lu.se.
Lund University · SEFeinstein Institute for Medical Research · USMedicon Village · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies-and-standards/article-withdrawal). This article has been retracted at the request of the Authors. It has come to the authors' attention that Figure 2 in their paper contains overlapping regions in the electron microscopy image. They consulted the microscopist responsible for the images, who provided the following explanation: “Taurocholate+Vehicle (C) originates from the same specimen as Taurocholate+C23 (C), although from two different experiments. In the Taurocholate+Vehicle condition, the thin sections were first labeled with antibodies and then imaged. In subsequent control experiments, all gold label was stripped from the thin sections by metaperiodate treatment and, as a control, the same thin sections were relabeled with control antibodies. This accounts for the differing gold patterns in the repetitive areas between Taurocholate+Vehicle (C) and Taurocholate+C23 (C). Potential repetitive areas within Sham+Vehicle (C) presumably arise from the Residual Bulk Image (RBI) phenomenon of the CCD camera, in which structures may be digitally repeated due to charge residues in the camera wafer.” Although this explanation appears reasonable, the authors acknowledge that none of them possess the expertise required to fully assess the matter. While the conclusions of the paper remain valid and the electron microscopy images served only to support other findings, the authors recognize that the quality of these images does not meet the standards necessary for publication. They therefore believe that retraction of the paper is warranted and express their sincere regret for the situation. The statement is issued by Johan Linders, Raed Madhi, Milladur Rahman, Matthias Mörgelin, Max Brenner, Ping Wang, and Henrik Thorlacius. Author Sara Regner could not be reached for comment.

Indexed as

PancreasPancreatitisRNA-Binding ProteinsAcinar CellsAdultAnimalsCells, CulturedCytokinesExtracellular TrapsFemaleHumansMaleMiceMice, Inbred C57BLCIRBP protein, humanCirbp protein, mouseCytokinesRNA-Binding Proteins

Identifiers

PMID32709888
OpenAlexW3045078410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.