ArticleLaboratory investigation; a journal of technical methods and pathology2020
RETRACTED: Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis
Article in Laboratory investigation; a journal of technical methods and pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- DAMP signaling networks: from receptors to diverse pathophysiological functions.Journal of advanced research · 2026Review
- CIRP contributes to multiple organ damage in acute pancreatitis by increasing endothelial permeability.Communications biology · 2025Article
- Inhibition of CD53 Reduces the Formation of ROS-Induced Neutrophil Extracellular Traps and Protects Against Inflammatory Injury in Acute Pancreatitis.Journal of inflammation research · 2025Article
- Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells.Cell death discovery · 2024Article
- Circulating cold-inducible RNA-binding protein levels in microscopic polyangiitis and granulomatosis with polyangiitis : Correlation with disease activity.Zeitschrift fur Rheumatologie · 2024Article
- Review
- Recent advances in the role of neutrophils and neutrophil extracellular traps in acute pancreatitis.Clinical and experimental medicine · 2023Review
- Targeting extracellular CIRP with an X-aptamer shows therapeutic potential in acute pancreatitis.iScience · 2023Article
- High expression of P-selectin induces neutrophil extracellular traps via the PSGL-1/Syk/CaFrontiers in immunology · 2023Article
- Hemorheological and Microcirculatory Relations of Acute Pancreatitis.Metabolites · 2022Review
- Fighting Fire with Fire: Exosomes and Acute Pancreatitis-Associated Acute Lung Injury.Bioengineering (Basel, Switzerland) · 2022Review
- TREM-1 Modulation Strategies for Sepsis.Frontiers in immunology · 2022Review
- Roles, detection, and visualization of neutrophil extracellular traps in acute pancreatitis.Frontiers in immunology · 2022Review
- Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis.Frontiers in cellular and infection microbiology · 2022Review
- Article
- The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior.Cell & bioscience · 2021Review
- Release mechanisms of major DAMPs.Apoptosis : an international journal on programmed cell death · 2021Review
- Article
- Cold-Induced RNA-Binding Protein Promotes Glucose Metabolism and Reduces Apoptosis by Increasing AKT Phosphorylation in Mouse Skeletal Muscle Under Acute Cold Exposure.Frontiers in molecular biosciences · 2021Article
- Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1Frontiers in pharmacology · 2021Article
Corrections and comments
- Retraction · 2026-02-17Concerns/Issues about Image ·
- Retracted
- Retracted
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies-and-standards/article-withdrawal). This article has been retracted at the request of the Authors. It has come to the authors' attention that Figure 2 in their paper contains overlapping regions in the electron microscopy image. They consulted the microscopist responsible for the images, who provided the following explanation: “Taurocholate+Vehicle (C) originates from the same specimen as Taurocholate+C23 (C), although from two different experiments. In the Taurocholate+Vehicle condition, the thin sections were first labeled with antibodies and then imaged. In subsequent control experiments, all gold label was stripped from the thin sections by metaperiodate treatment and, as a control, the same thin sections were relabeled with control antibodies. This accounts for the differing gold patterns in the repetitive areas between Taurocholate+Vehicle (C) and Taurocholate+C23 (C). Potential repetitive areas within Sham+Vehicle (C) presumably arise from the Residual Bulk Image (RBI) phenomenon of the CCD camera, in which structures may be digitally repeated due to charge residues in the camera wafer.” Although this explanation appears reasonable, the authors acknowledge that none of them possess the expertise required to fully assess the matter. While the conclusions of the paper remain valid and the electron microscopy images served only to support other findings, the authors recognize that the quality of these images does not meet the standards necessary for publication. They therefore believe that retraction of the paper is warranted and express their sincere regret for the situation. The statement is issued by Johan Linders, Raed Madhi, Milladur Rahman, Matthias Mörgelin, Max Brenner, Ping Wang, and Henrik Thorlacius. Author Sara Regner could not be reached for comment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.