ArticleTranslational psychiatry2020
Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Subjective sleep quality predict clinical pain severity more strongly than polysomnographic parameters: Machine learning findings from a cross-sectional study.Sleep medicine · 2026Article
- Genetic risk of chronic pain conditions associated with risk of suicide death through an integrative analysis of EHR and genomics data.Translational psychiatry · 2026Article
- Joint association of chronic pain and sleep patterns with cardiovascular diseases: a prospective study.BMC public health · 2026Article
- Biomarkers and Breakdowns: Neuroinflammatory Drivers Linking Sleep Disorders and Chronic Pain.Biomedicines · 2026Review
- Sleep duration and pain during the COVID-19 pandemic with depression and chronic diseases as mediators.Scientific reports · 2024Article
- Cognitive horizons in chronic pain: unraveling neuroscientific insights and innovative interventions for fibromyalgia.European archives of psychiatry and clinical neuroscience · 2024Article
- Elevated pain sensitivity is associated with reduced rapid eye movement (REM) sleep in females with comorbid temporomandibular disorder and insomnia.Pain medicine (Malden, Mass.) · 2024Article
- Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024Review
- A common neuronal ensemble in nucleus accumbens regulates pain-like behaviour and sleep.Nature communications · 2023Article
- Back Pain without Disease or Substantial Injury in Children and Adolescents: A Twin Family Study Investigating Genetic Influence and Associations.Children (Basel, Switzerland) · 2023Article
- Leveraging genetic discoveries for sleep to determine causal relationships with common complex traits.Sleep · 2022Review
- The Impact of Quarantine on Pain Sensation among the General Population in China during the COVID-19 Pandemic.Brain sciences · 2022Article
- Home-Based EEG Neurofeedback Intervention for the Management of Chronic Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Causal association of sleep disturbances and low back pain: A bidirectional two-sample Mendelian randomization study.Frontiers in neuroscience · 2022Article
- Abnormal Visual Evoked Responses to Emotional Cues Correspond to Diagnosis and Disease Severity in Fibromyalgia.Frontiers in behavioral neuroscience · 2022Article
- The Human Connectome Project: A retrospective.NeuroImage · 2021Review
- Comorbid Chronic Pain and Depression: Shared Risk Factors and Differential Antidepressant Effectiveness.Frontiers in psychiatry · 2021Article
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Corrections and comments
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
Abstract
Chronic pain and sleep disturbance are highly comorbid disorders, which leads to barriers to treatment and significant healthcare costs. Understanding the underlying genetic and neural mechanisms of the interplay between sleep disturbance and chronic pain is likely to lead to better treatment. In this study, we combined 1206 participants with phenotype data, resting-state functional magnetic resonance imaging (rfMRI) data and genotype data from the Human Connectome Project and two large sample size genome-wide association studies (GWASs) summary data from published studies to identify the genetic and neural bases for the association between pain and sleep disturbance. Pittsburgh sleep quality index (PSQI) score was used for sleep disturbance, pain intensity was measured by Pain Intensity Survey. The result showed chronic pain was significantly correlated with sleep disturbance (r = 0.171, p-value < 0.001). Their genetic correlation was r
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.