ArticleProceedings of the National Academy of Sciences of the United States of America2020
Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 94 citations in OpenAlex.
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026Review
- TheProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pattern Recognition Receptors in Plant Immunity.Advances in experimental medicine and biology · 2025Review
- Identification and validation of paraptosis-related biomarkers in recurrent miscarriage.Frontiers in immunology · 2025Article
- Pathogen perception and signaling in plant immunity.The Plant cell · 2024Review
- Article
- Plant NLR immunity activation and execution: a biochemical perspective.Open biology · 2024Review
- Resistance that stacks up: engineering rust and mildew disease control in the cereal crops wheat and barley.Plant biotechnology journal · 2023Review
- Signaling and Resistosome Formation in Plant Innate Immunity to Viruses: Is There a Common Mechanism of Antiviral Resistance Conserved across Kingdoms?International journal of molecular sciences · 2023Review
- Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity.Cell research · 2023Article
- Resurrection of plant disease resistance proteins via helper NLR bioengineering.Science advances · 2023Article
- Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products.Science advances · 2023Article
- Oligomerization of a plant helper NLR requires cell-surface and intracellular immune receptor activation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens.The EMBO journal · 2023Article
- Pangenomic analysis reveals plant NADProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The intracellular immune receptor like gene SNC1 is an enhancer of effector-triggered immunity in Arabidopsis.Plant physiology · 2023Article
- Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1.Plant physiology · 2023Article
- Differential requirement of TIR enzymatic activities in TIR-type immune receptor SNC1-mediated immunity.Plant physiology · 2022Article
- Bacterial origins of human cell-autonomous innate immune mechanisms.Nature reviews. Immunology · 2022Review
Corrections and comments
- Commented on by
Authors and funding
19 authors at 5 institutions in 10 countries.
Funding
Abstract
Plant and animal intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors detect pathogen-derived molecules and activate defense. Plant NLRs can be divided into several classes based upon their N-terminal signaling domains, including TIR (Toll-like, Interleukin-1 receptor, Resistance protein)- and CC (coiled-coil)-NLRs. Upon ligand detection, mammalian NAIP and NLRC4 NLRs oligomerize, forming an inflammasome that induces proximity of its N-terminal signaling domains. Recently, a plant CC-NLR was revealed to form an inflammasome-like hetero-oligomer. To further investigate plant NLR signaling mechanisms, we fused the N-terminal TIR domain of several plant NLRs to the N terminus of NLRC4. Inflammasome-dependent induced proximity of the TIR domain in planta initiated defense signaling. Thus, induced proximity of a plant TIR domain imposed by oligomerization of a mammalian inflammasome is sufficient to activate authentic plant defense. Ligand detection and inflammasome formation is maintained when the known components of the NLRC4 inflammasome is transferred across kingdoms, indicating that NLRC4 complex can robustly function without any additional mammalian proteins. Additionally, we found NADase activity of a plant TIR domain is necessary for plant defense activation, but NADase activity of a mammalian or a bacterial TIR is not sufficient to activate defense in plants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.