ArticleProceedings of the National Academy of Sciences of the United States of America2020
Thinner biological tissues induce leaflet flutter in aortic heart valve replacements.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 95 citations in OpenAlex.
- Parameterized shape optimization of a bi-leaflet heart valved conduit for pediatric applications.Engineering with computers · 2026Article
- Small patients - Big needs: A material-based approach to develop miniaturised valves for congenital heart diseases.Bioactive materials · 2026Article
- Understanding the mechanisms of TAVI durability through computational modelling: a multidisciplinary review.European heart journal. Digital health · 2026Review
- Modes of Leaflet Fluttering: Quantitative Characterization of a Bovine Bioprosthetic Heart Valve.Annals of biomedical engineering · 2026Article
- ValveFit: An analysis-suitable B-spline-based surface fitting framework for patient-specific modeling of tricuspid valves.Computer methods in applied mechanics and engineering · 2026Article
- A reduced 3D-0D fluid-structure interaction model of the aortic valve that includes leaflet curvature.Biomechanics and modeling in mechanobiology · 2025Article
- The impact of coronary outflow and non-Newtonian fluid property on aortic valve haemodynamics.Biomechanics and modeling in mechanobiology · 2025Article
- Computational construction and design optimization of a novel tri-tube heart valve.Biomechanics and modeling in mechanobiology · 2025Article
- Thrombogenic Risk Assessment of Transcatheter Prosthetic Heart Valves Using a Fluid-Structure Interaction Approach.Computer methods and programs in biomedicine · 2024Article
- Analysis of Fluid-Structure Interaction Mechanisms for a Native Aortic Valve, Patient-Specific Ozaki Procedure, and a Bioprosthetic Valve.Annals of biomedical engineering · 2024Article
- Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model.Journal of biomechanical engineering · 2024Article
- Multiscale structure and function of the aortic valve apparatus.Physiological reviews · 2024Review
- Article
- In Vitro Proof of Concept of a First-Generation Growth-Accommodating Heart Valved Conduit for Pediatric Use.Macromolecular bioscience · 2023Article
- Analysis of the Effect of Thickness on the Performance of Polymeric Heart Valves.Journal of functional biomaterials · 2023Article
- A Doppler-exclusive non-invasive computational diagnostic framework for personalized transcatheter aortic valve replacement.Scientific reports · 2023Article
- Biomechanical Engineering Analysis of Pulmonary Valve Leaflet Hemodynamics and Kinematics in the Ross Procedure.Journal of biomechanical engineering · 2023Article
- Leaflet Stresses During Full Device Simulation of Crimping to 6 mm in Transcatheter Aortic Valve Implantation, TAVI.Cardiovascular engineering and technology · 2022Article
- Poly-2-methyl-2-oxazoline-modified bioprosthetic heart valve leaflets have enhanced biocompatibility and resist structural degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Effects of membrane and flexural stiffnesses on aortic valve dynamics: identifying the mechanics of leaflet flutter in thinner biological tissues.Forces in mechanics · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Valvular heart disease has recently become an increasing public health concern due to the high prevalence of valve degeneration in aging populations. For patients with severely impacted aortic valves that require replacement, catheter-based bioprosthetic valve deployment offers a minimally invasive treatment option that eliminates many of the risks associated with surgical valve replacement. Although recent percutaneous device advancements have incorporated thinner, more flexible biological tissues to streamline safer deployment through catheters, the impact of such tissues in the complex, mechanically demanding, and highly dynamic valvular system remains poorly understood. The present work utilized a validated computational fluid-structure interaction approach to isolate the behavior of thinner, more compliant aortic valve tissues in a physiologically realistic system. This computational study identified and quantified significant leaflet flutter induced by the use of thinner tissues that initiated blood flow disturbances and oscillatory leaflet strains. The aortic flow and valvular dynamics associated with these thinner valvular tissues have not been previously identified and provide essential information that can significantly advance fundamental knowledge about the cardiac system and support future medical device innovation. Considering the risks associated with such observed flutter phenomena, including blood damage and accelerated leaflet deterioration, this study demonstrates the potentially serious impact of introducing thinner, more flexible tissues into the cardiac system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.