ArticleJournal of the American Society of Nephrology : JASN2020
Podocyte Integrin-
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In one paragraph
Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Targeting Integrin β3 in Endothelial Cells Attenuates Cardiac Fibrosis Through the Calcium-Calmodulin-Dependent Protein Kinase IIα- cAMP-Responsive Element Binding Protein 1 Signaling Axis in Pressure Overload-Induced Heart Failure.Journal of the American Heart Association · 2026Article
- Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36-Dependent Lipid Uptake Complex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Biomimetic fractal topography enhances podocyte maturation in vitro.Nature communications · 2025Article
- Loss of RhoA in microglia disables glycolytic adaptation and impairs spinal cord injury recovery through Arhgap25/HIF-1α pathway.Cell death & disease · 2025Article
- The integrin repertoire drives YAP-dependent epithelial:stromal interactions during injury of the kidney glomerulus.Nature communications · 2025Article
- ANGPTL3 accelerates atherosclerotic progression via direct regulation of M1 macrophage activation in plaque.Journal of advanced research · 2025Article
- Integrins in the kidney - beyond the matrix.Nature reviews. Nephrology · 2025Review
- Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/IntegrinJournal of diabetes research · 2025Article
- Urolithin A Ameliorates the TGF Beta-Dependent Impairment of Podocytes Exposed to High Glucose.Journal of personalized medicine · 2024Article
- Article
- Review
- Cellular crosstalk of glomerular endothelial cells and podocytes in diabetic kidney disease.Journal of cell communication and signaling · 2022Review
- Activated Protein C Ameliorates Tubular Mitochondrial Reactive Oxygen Species and Inflammation in Diabetic Kidney Disease.Nutrients · 2022Article
- Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis.Communications biology · 2022Article
- Neutrophil Extracellular Traps Promote NLRP3 Inflammasome Activation and Glomerular Endothelial Dysfunction in Diabetic Kidney Disease.Nutrients · 2022Article
- Article
- Article
- The role and mechanism of butyrate in the prevention and treatment of diabetic kidney disease.Frontiers in microbiology · 2022Review
- Activated Protein C Ameliorates Diabetic CardiomyopathyFrontiers in cardiovascular medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 11 institutions in 4 countries.
Thati MadhusudhanInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany m.thati@uni-mainz.de berend.isermann@medizin.uni-leipzig.de.
Sanchita GhoshInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Hongjie WangInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Wei DongInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Dheerendra GuptaInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Ahmed ElwakielInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Stoyan StoyanovGerman Center for Neurodegenerative Diseases, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Moh'd Mohanad Al-DabetInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Shruthi KrishnanInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Ronald BiemannInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Sumra NazirInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Silke ZimmermannInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Akash MathewInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.ORCID 0000-0002-3210-9479
Ihsan GadiInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Rajiv RanaInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Jinyang Zeng-BrouwersInstitute of Pharmacology, University Hospital and Goethe University, Frankfurt, Germany.
Marcus J MoellerDivision of Nephrology and Immunology, University Hospital of the Rheinisch-Westfälische Technische Hochschule, Aachen University of Technology, Aachen, Germany.
Liliana SchaeferInstitute of Pharmacology, University Hospital and Goethe University, Frankfurt, Germany.
Charles T EsmonCoagulation Biology Laboratory, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Shrey KohliInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Jochen ReiserDepartment of Medicine, Rush University Medical Center, Chicago, Illinois.
Alireza R RezaieCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Wolfram RufCenter for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.
Berend IsermannInstitute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany m.thati@uni-mainz.de berend.isermann@medizin.uni-leipzig.de.
University Hospital Leipzig · DEGoethe University Frankfurt · DEOklahoma Medical Research Foundation · USOtto-von-Guericke-Universität Magdeburg · DEAmerican University of Madaba · JOGerman Center for Neurodegenerative Diseases · DEJohannes Gutenberg University Mainz · DERush University Medical Center · USRWTH Aachen University · DEScripps Research Institute · USTongji Hospital · CN
Funding
Protease Activated Receptor Signaling by Coagulation ProteasesR01HL101917 · NHLBI · SAINT LOUIS UNIVERSITY · PI Lijun Xia · 2010 to 2026
$6.6MNHLBI NIH HHS R01 HL101917
Abstract
backgroundDiabetic nephropathy (dNP), now the leading cause of ESKD, lacks efficient therapies. Coagulation protease-dependent signaling modulates dNP, in part
methodsA combination of
resultsThe zymogen protein C and aPC bind to podocyte integrin-
Indexed as
AnimalsCytoprotectionDiabetic NephropathiesEndothelial Protein C ReceptorGTP-Binding Protein alpha Subunits, G12-G13HEK293 CellsHumansIntegrin beta3MiceMice, Inbred C57BLPodocytesProtein CReceptor, PAR-1rhoA GTP-Binding ProteinEndothelial Protein C ReceptorGNA13 protein, humanGTP-Binding Protein alpha Subunits, G12-G13Integrin beta3Protein CReceptor, PAR-1rhoA GTP-Binding Proteinactivated protein Ccoagulation proteasesdiabetic nephropathyintegrin αvβ3RhoA signaling
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What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.