Evidence map›Paper›PMID 32709695›Full record

ArticleBiology open2020

Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model.

Kavita Mallya, Dhanya Haridas, Parthasarathy Seshacharyulu, Ramesh Pothuraju, Wade M Junker, Shiv Ram Krishn, Sakthivel Muniyan, Raghupathy Vengoji, Surinder K Batra, Satyanarayana Rachagani

Open access · goldAbstract read
In one paragraph

Article in Biology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kavita MallyaDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.
Dhanya HaridasDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.ORCID 0000-0002-6146-6168
Parthasarathy SeshacharyuluDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.ORCID 0000-0002-2348-3901
Ramesh PothurajuDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.ORCID 0000-0002-0216-2578
Wade M JunkerDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.ORCID 0000-0002-2649-3996
Shiv Ram KrishnDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.ORCID 0000-0002-4770-6671
Sakthivel MuniyanDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.ORCID 0000-0001-9405-7857
Raghupathy VengojiDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.ORCID 0000-0002-6914-3048
Surinder K BatraDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA srachagani@unmc.edu sbatra@unmc.edu.ORCID 0000-0001-9470-9317
Satyanarayana RachaganiDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA srachagani@unmc.edu sbatra@unmc.edu.ORCID 0000-0003-3949-8566
University of Nebraska Medical Center · US

Funding

Project 3: MUC16-Mediated Metabolic Reprograming Induces PC MetastasisP01CA217798 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THAYER, SARAH P · 2018 to 2022
$8.1M
Targeted Radiation Therapy for Pancreatic CancerR01CA195586 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K., JAIN, MANEESH · 2015 to 2019
$2.2M
Rac1 GTPase in tumorigenesis and progression of pancreatic cancerR01CA206444 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K., OUELLETTE, MICHEL M · 2016 to 2020
$1.9M
Targeting Mucin and EGFR Axis in Pancreatic CancerR01CA183459 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K. · 2014 to 2018
$1.6M
Altered Histidine Metabolism in Pancreatic Cancer: A Novel Metabolic Target to Enhance Gemcitabine EfficacyR21CA238953 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RACHAGANI, SATYANARAYANA, VISWANATHAN, SARASWATHI · 2019 to 2020
$372k
NCI NIH HHS P01 CA217798NCI NIH HHS R01 CA183459NCI NIH HHS R01 CA195586NCI NIH HHS R01 CA206444NCI NIH HHS R21 CA238953
6 · The paper itself

Abstract

Pancreatic cancer (PC) is acquired postnatally; to mimic this scenario, we developed an inducible Kras

Indexed as

AnimalsBiomarkersCarcinoma, Pancreatic DuctalCell Transformation, NeoplasticDisease Models, AnimalDisease ProgressionDisease SusceptibilityGene ExpressionImmunohistochemistryMiceMucinsMultigene FamilyPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)TamoxifenTranscription FactorsBiomarkersKRAS protein, humanMucinsProto-Oncogene Proteins p21(ras)TamoxifenTranscription FactorsInducible KC (iKC) mouse modelMucinPancreatic ductal adenocarcinoma (PDAC)

Identifiers

PMID32709695
PMCPMC7502593
OpenAlexW3044417071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.