Evidence map›Paper›PMID 32709692›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Histaminergic Control of Corticostriatal Synaptic Plasticity during Early Postnatal Development.

Sungwon Han, Ricardo Márquez-Gómez, Myles Woodman, Tommas Ellender

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sungwon HanDepartment of Pharmacology, University of Oxford, OX1 3QT, Oxford, United Kingdom.
Ricardo Márquez-GómezDepartment of Pharmacology, University of Oxford, OX1 3QT, Oxford, United Kingdom.ORCID 0000-0002-5810-2670
Myles WoodmanDepartment of Pharmacology, University of Oxford, OX1 3QT, Oxford, United Kingdom.
Tommas EllenderDepartment of Pharmacology, University of Oxford, OX1 3QT, Oxford, United Kingdom tommas.ellender@pharm.ox.ac.uk.ORCID 0000-0001-9787-3307

Funding

Medical Research Council MR/M009599/1
6 · The paper itself

Abstract

A reduction in the synthesis of the neuromodulator histamine has been associated with Tourette's syndrome and obsessive-compulsive disorder. Symptoms of these disorders are thought to arise from a dysfunction or aberrant development ofcorticostriatal circuits. Here, we investigated how histamine affects developing corticostriatal circuits, both acutely and longer-term, during the first postnatal weeks, using patch-clamp and field recordings in mouse brain slices (C57Bl/6, male and female). Immunohistochemistry for histamine-containing axons reveals striatal histaminergic innervation by the second postnatal week, and qRT-PCR shows transcripts for H

Indexed as

Neuronal PlasticityAnimalsCerebral CortexCorpus StriatumFemaleHistamineMaleMembrane PotentialsMice, Inbred C57BLNeural PathwaysReceptors, HistamineReceptors, Histamine H1Receptors, Histamine H2Receptors, Histamine H3Synaptic TransmissionHistamineReceptors, HistamineReceptors, Histamine H1Receptors, Histamine H2Receptors, Histamine H3basal gangliacortexdevelopmenthistaminestriatumsynaptic plasticity

Identifiers

PMID32709692
PMCPMC7486653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.