Evidence map›Paper›PMID 32709660›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease.

Kirsten M Anderson, Danillo G Augusto, Ravi Dandekar, Hengameh Shams, Chao Zhao, Tasneem Yusufali, Gonzalo Montero-Martín, Wesley M Marin, Neda Nemat-Gorgani, Lisa E Creary and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Human leukocyte antigen in Parkinson's disease: A systematic review and meta-analysis of risk and clinical attributes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. The Role of Killer Ig-like Receptors in Diseases from A to Z.International journal of molecular sciences · 2025
    Review
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  18. Article
  19. High-Resolution Characterization ofFrontiers in immunology · 2021
    Article
  20. An immunogenetic view of COVID-19.Genetics and molecular biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Kirsten M AndersonDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.ORCID 0000-0002-8411-0623
Danillo G AugustoDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.
Ravi DandekarDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.
Hengameh ShamsDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.
Chao ZhaoDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.
Tasneem YusufaliDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.
Gonzalo Montero-MartínDepartment of Pathology, Stanford University School of Medicine, Palo Alto, CA 94304.
Wesley M MarinDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.
Neda Nemat-GorganiDepartment of Structural Biology and Immunology, Stanford University, Palo Alto, CA 94305.
Lisa E CrearyDepartment of Pathology, Stanford University School of Medicine, Palo Alto, CA 94304.
Stacy CaillierDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.
Mohammad R K MofradMolecular Cell Biomechanics Laboratory, Department of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA 94720; and.ORCID 0000-0001-7004-4859
Peter ParhamDepartment of Structural Biology and Immunology, Stanford University, Palo Alto, CA 94305.
Marcelo Fernández-ViñaDepartment of Pathology, Stanford University School of Medicine, Palo Alto, CA 94304.ORCID 0000-0002-5707-2588
Jorge R OksenbergDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.
Paul J NormanDivision of Biomedical Informatics and Personalized Medicine, Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Jill A HollenbachDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158; jill.hollenbach@ucsf.edu.ORCID 0000-0001-6572-7962
University of California, San Francisco · USPalo Alto University · USUniversity of California, Berkeley · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Insights Into Immune-Related Diseases Born from Population GenomicsU01AI090905 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Paul John Norman · 2010 to 2026
$10.9M
KIR association studies in neurological diseasesU19NS095774 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERNANDEZ-VINA, MARCELO, OKSENBERG, JORGE R. · 2015 to 2019
$7.0M
NIAID NIH HHS U01 AI090905NINDS NIH HHS U19 NS095774
6 · The paper itself

Abstract

Immune dysfunction plays a role in the development of Parkinson disease (PD). NK cells regulate immune functions and are modulated by killer cell immunoglobulin-like receptors (KIR). KIR are expressed on the surface of NK cells and interact with HLA class I ligands on the surface of all nucleated cells. We investigated

Indexed as

AllelesFemaleGenotypeHLA-B AntigensHumansKiller Cells, NaturalLigandsMaleMiddle AgedParkinson DiseasePolymorphism, GeneticReceptors, KIR3DL1Severity of Illness IndexHLA-B AntigensHLA-Bw4 antigenKIR3DL1 protein, humanLigandsReceptors, KIR3DL1

Identifiers

PMID32709660
PMCPMC7484130
OpenAlexW3044509503

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.