ArticleJournal of pediatric surgery2021
Intestinal adaptation following spring insertion into a roux limb in mice.
Article in Journal of pediatric surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Epithelial ion transport in spring-lengthened jejunum in a porcine model.Journal of pediatric surgery · 2026Article
- Molecular Mechanisms of Intestinal Adaptation in Short Bowel Syndrome: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Submucosal Hydrogel for Spring-Mediated Intestinal Lengthening.Journal of biomedical materials research. Part A · 2025Article
- Mechanical distraction enterogenesis utilizing springs has equal effectiveness in adult and juvenile pigs.Pediatric surgery international · 2024Article
- Spring-mediated distraction enterogenesis may alter the course of adaptation in porcine short bowel syndrome.Frontiers in gastroenterology (Lausanne, Switzerland) · 2024Article
- Stem cell activation during distraction enterogenesis in the murine colon.Pediatric surgery international · 2023Article
- Long-term safety of intraluminal spring-mediated bowel lengthening.Journal of pediatric surgery · 2023Article
- The effect of spring diameter on porcine ileal distraction enterogenesis.Pediatric surgery international · 2022Article
- Surgical Treatment of Short Bowel Syndrome-The Past, the Present and the Future, a Descriptive Review of the Literature.Children (Basel, Switzerland) · 2022Review
- Article
- Self-expanding intestinal expansion sleeves (IES) for short gut syndrome.Pediatric surgery international · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
background/purposeIntraluminal springs have recently been shown to lengthen segments of intestine in a process known as distraction enterogenesis. We hypothesized that biocompatible springs could be used to lengthen defunctionalized murine small intestine and would lead to identifiable intestinal adaptations at the molecular level.
methodsAge and weight matched C57BL/6 mice underwent surgical insertion of nitinol spring-loaded capsules into a Roux limb of jejunum. Segment lengths were measured at initial spring placement and at euthanasia after 14 and 21 days. Histology and gene expression of the Roux limb were evaluated at scarification and compared to untreated control segments.
resultsIntestinal segments loaded with compressed springs lengthened an average of 240%, which was significantly longer than control segments loaded with either empty capsules or uncompressed springs. Muscularis thickening was greater in spring-treated mice compared to controls without springs. Crypt depth and Lgr5+ expression was greater in mice that received compressed spring treatments when compared to control groups.
conclusionsInsertion of a compressed nitinol spring into a Roux limb results in significant intestinal lengthening, smooth muscle thickening, and Lgr5+ expression in a mouse model. The ability to increase small bowel length in a defunctionalized murine model may be used to understand the mechanism of distraction enterogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.