ReviewRedox biology2020
The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness.
Review in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Association of social isolation, loneliness and risk of cardiovascular diseases: Meta-analysis of cohort studies.BMC public health · 2025Pooled it
- Social Isolation, Loneliness, and Cardiovascular Mortality: The Role of Health Care System Interventions.Current cardiology reports · 2024Pooled it
- A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality.Nature human behaviour · 2023Pooled it
- Association of Intensive Blood Pressure Control and Living Arrangement on Cardiovascular Outcomes by Race: Post Hoc Analysis of SPRINT Randomized Clinical Trial.JAMA network open · 2022Trial
- Social Isolation, Loneliness and Subclinical Atherosclerosis.Current atherosclerosis reports · 2026Review
- The Effects of Open-World and Fun, Accessible Games on Perceived Loneliness and Stoicism in Adults: Cross-Sectional Survey Study.JMIR serious games · 2026Article
- Coronary Artery Disease and Loneliness: A Cross-Sectional Analysis using the Revised UCLA Loneliness Scale.The International journal of angiology : official publication of the International College of Angiology, Inc · 2026Article
- Unraveling 'F' factor: towards a genetic-clinical framework for the musculoskeletal-heart crosstalk in metabolic aging.Cardiovascular diabetology · 2026Article
- Association between social isolation, loneliness and the incidence of irritable bowel syndrome: a prospective cohort study in the UK Biobank.Annals of general psychiatry · 2026Article
- Living arrangements and cognitive resilience in aging: unraveling distinct pathways through plasma biomarkers.The journal of prevention of Alzheimer's disease · 2026Article
- Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants.Nature communications · 2026Article
- Social Disconnection, Genetic Risk, and the Incidence of Degenerative Valvular Heart Disease: A Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- Association Between Depressive Symptoms and Incidence of Stroke in a Population With Cardiovascular-Kidney-Metabolic Syndrome Stages 0 to 3: Nationwide Prospective Cohort Study.Interactive journal of medical research · 2026Article
- A study of the associations between social isolation and loneliness with sex-specific cancer risk in the UK Biobank.Communications medicine · 2026Article
- Article
- Social isolation, loneliness, genetic susceptibility, and the hazard of incident osteoporosis.International journal of surgery (London, England) · 2026Article
- Loneliness and all-cause mortality in the United States.PloS one · 2026Article
- Diagnostic and therapeutic innovations in myocardial infarction: a focus on mitochondrial dysfunction.Frontiers in cardiovascular medicine · 2026Review
- Neural-immune-cardiovascular axis: from mechanistic crosstalk to therapeutic targets in cardiovascular disease.Frontiers in immunology · 2026Review
- Association of loneliness with incident cardiovascular diseases in middle-aged and older Chinese adults.PloS one · 2026Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loneliness and social isolation are common sources of chronic stress in modern society. Epidemiological studies have demonstrated that loneliness and social isolation increase mortality risk as much as smoking or alcohol consumption and more than physical inactivity or obesity. Loneliness in human is associated with higher blood pressure whereas enhanced atherosclerosis is observed in animal models of social isolation. Loneliness and social isolation lead to activation of the hypothalamic-pituitary-adrenocortical (HPA) axis, enhanced sympathetic nerve activity, impaired parasympathetic function and a proinflammatory immune response. These mechanisms have been implicated in the development of cardiovascular disease conferred by social isolation although a causal relationship has not been established so far. There is evidence that oxidative stress is likely to be a key molecular mechanism linking chronic psychosocial stress to cardiovascular disease. NADPH oxidase-mediated oxidative stress in the hypothalamus has been shown to be required for social isolation-induced HPA axis activation in socially isolated rats. Oxidative stress in the rostral ventrolateral medulla is also a key regulator of sympathetic nerve activity. In the vasculature, oxidative stress increases vascular tone and promote atherogenesis through multiple mechanisms. Thus, preventing oxidative stress may represent a therapeutic strategy to reduce the detrimental effects of social stress on health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.