ReviewBiological psychiatry2021
Posttraumatic Stress Disorder and the Developing Adolescent Brain.
Review in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Prevalence of war-related posttraumatic stress disorder in adolescents: a systematic review and meta-analysis.European journal of psychotraumatology · 2025Pooled it
- Early biological and psychosocial factors associated with PTSD onset and persistence in youth.European journal of psychotraumatology · 2024Pooled it
- Neurobiological Alterations in Females With PTSD: A Systematic Review.Frontiers in psychiatry · 2022Pooled it
- Diagnostic comparisons of PTSD and complex PTSD in clinical adolescents: Detection rates and ACEs as risk factors.European journal of psychotraumatology · 2026Article
- The neuropsychological impact of early childhood trauma on cognitive development: A narrative review of mechanisms, outcomes, and interventions.PCN reports : psychiatry and clinical neurosciences · 2026Review
- Changes in the network temperature of posttraumatic stress disorder symptoms among children and adolescents following earthquakes.Psychological medicine · 2026Article
- Traditional Fermented Multi-Grain Supernatant (Ogi-baba Omidun) Restores Hypothalamic-Pituitary-Testicular Axis Function in a Juvenile Double-Hit PTSD-Neuroinflammation Rat Model.Molecular neurobiology · 2026Article
- Posttraumatic stress disorder from early childhood to late adolescence: a resilience-oriented approach to prevention, diagnosis, and clinical management.Discover mental health · 2026Review
- The Effects of Boko Haram Terrorism on Adolescents' and Young Adults' Psychosocial Adjustment in the Northeast of Nigeria.Transcultural psychiatry · 2026Article
- Post-traumatic stress disorder.Nature reviews. Disease primers · 2026Review
- Mental health after compounding natural hazard exposure in New South Wales from 2019 to 2023: a cross-sectional study in Australian youth.Scientific reports · 2026Article
- A Mixed-Methods Analysis of Trauma-Exposed Adolescents' Gastrointestinal Symptoms as Captured in Online Social Communication.Neurogastroenterology and motility · 2026Article
- Association of Sleep Quality, Sleep Disturbances, and Chronotype with Post-Traumatic Stress Disorder in Earthquake-Exposed Adolescents.Children (Basel, Switzerland) · 2026Article
- Peripheral immune system activity in young psychiatry patients.Brain, behavior, & immunity - health · 2026Article
- Event-related potentials associated with cognitive control in adolescents exposed to complex childhood trauma.European journal of psychotraumatology · 2025Article
- The associations between PTSD symptoms, intolerance of uncertainty and personal growth initiative in trauma-exposed children and adolescents: undirected and Bayesian network analyses.European child & adolescent psychiatry · 2025Article
- Alcohol Drinking and the Associations Between Age and Posttraumatic Stress Disorder: A 2-Year Longitudinal Study.Psychiatry investigation · 2025Article
- Resilience as a Predictor of Indirect Trauma Among Korean Adolescents: A Cross-Sectional Correlational Study.Healthcare (Basel, Switzerland) · 2025Article
- Post-Traumatic Stress in Adolescence: The Mediating Role of Time Perspective Between Trauma Exposure, PTSD Symptoms, and Cannabis Use.European journal of investigation in health, psychology and education · 2025Article
- Cannabis involvement in posttraumatic stress disorder emergency department visits after cannabis legalization.The American journal on addictions · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Posttraumatic stress disorder (PTSD) in adolescents is common and debilitating. In contrast to adult PTSD, relatively little is known about the neurobiology of adolescent PTSD, nor about how current treatments may alter adolescent neurodevelopment to allow recovery from PTSD. Improving our understanding of biological mechanisms of adolescent PTSD, taken in the context of neurodevelopment, is crucial for developing novel and personalized treatment approaches. In this review, we highlight prevailing constructs of PTSD and current findings on these domains in adolescent PTSD. Notably, little data exist in adolescent PTSD for prominent adult PTSD constructs, including threat learning and attentional threat bias. Most work to date has examined general threat processing, emotion regulation, and their neural substrates. These studies suggest that adolescent PTSD, while phenomenologically similar to adult PTSD, shows unique neurodevelopmental substrates that may impair recovery but could also be targeted in the context of adolescent neuroplasticity to improve outcomes. Both cross-sectional and longitudinal data suggest abnormal frontolimbic development compared with typically developing youths, a pattern that may differ from resilient youths. Whether current treatments such as trauma-focused psychotherapy engage these targets and restore healthy neurodevelopment remains an open question. We end our review by highlighting emerging areas and knowledge gaps that could be addressed to better characterize the biology underlying adolescent PTSD. Emerging studies in computational modeling of decision making, caregiver-related transmission of traumatic stress, and other areas may offer new targets that could harness adolescent neurobehavioral plasticity to improve resilience and recovery for some of our most vulnerable youths.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.