Evidence map›Paper›PMID 32709378›Full record

SynthesisFertility and sterility2020

Association between male infertility and male-specific malignancies: systematic review and meta-analysis of population-based retrospective cohort studies.

Francesco Del Giudice, Alex M Kasman, Ettore De Berardinis, Gian Maria Busetto, Federico Belladelli, Michael L Eisenberg

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Fertility and sterility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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  19. Male Fertility as a Proxy for Health.Journal of clinical medicine · 2024
    Review
  20. Interplay between male gonadal function and overall male health.Journal of basic and clinical physiology and pharmacology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Francesco Del GiudiceDepartment of Maternal-Infant and Urological Sciences, "Sapienza" Rome University, Policlinico Umberto I Hospital, Rome, Italy; Department of Urology, School of Medicine, Stanford University, Stanford, California.
Alex M KasmanDepartment of Urology, School of Medicine, Stanford University, Stanford, California.
Ettore De BerardinisDepartment of Maternal-Infant and Urological Sciences, "Sapienza" Rome University, Policlinico Umberto I Hospital, Rome, Italy.
Gian Maria BusettoDepartment of Maternal-Infant and Urological Sciences, "Sapienza" Rome University, Policlinico Umberto I Hospital, Rome, Italy.
Federico BelladelliDepartment of Urology, School of Medicine, Stanford University, Stanford, California; Division of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS San Raffaele Hospital, and University Vita-Salute San Raffaele, Milan, Italy.
Michael L EisenbergDepartment of Urology, School of Medicine, Stanford University, Stanford, California; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, California. Electronic address: eisenberg@stanford.edu.
Policlinico Umberto I · ITStanford Medicine · USStanford University · USVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the current evidence that correlates impaired male fertility with the risk of developing male-related malignancies.

designSystematic review and meta-analysis of population-based retrospective cohort studies.

settingNot applicable. PATIENT(S): Men diagnosed with impaired fertility status and subsequently observed to determine incidence risk in developing testicular cancer (TCa) or prostate cancer (PCa). INTERVENTION(S): Not applicable. MAIN OUTCOME MEASURE(S): Pooled risk ratio (RR) differences among male factor infertility subjects compared with a fertile control population, and meta-regression analysis according to age at baseline, mean follow-up, range of study time, and year of publication. RESULT(S): Six studies met the inclusion criteria and were critically examined. Four studies examined male infertility and TCa (n = 161,634; 174 TCa cases), and four examined infertility in relation to PCa (n = 183,950 men; 377 PCa cases) from 1963 to 2014. The pooled RR was 2.033 (95% confidence interval [CI], 1.66-2.48); heterogeneity: Q = 3.04 (degree of freedom [df] = 3); I CONCLUSION(S): Male infertility was associated with a subsequent risk of both TCa and PCa. Although the clinical significance of these findings remains uncertain, future studies should evaluate the underlying mechanisms to determine whether testis and prostate screening practices should be altered in men with male infertility. CLINICAL TRIAL REGISTRATION NUMBER: PROSPERO 167277.

Indexed as

Population SurveillanceCohort StudiesHumansInfertility, MaleMaleProstatic NeoplasmsRetrospective StudiesRisk FactorsTesticular NeoplasmsEpidemiologymale factor infertilityprostate cancerrelative risktesticular cancer

Identifiers

PMID32709378
OpenAlexW3044002754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.