Evidence map›Paper›PMID 32709220›Full record

ArticleBMC pulmonary medicine2020

Do-not-resuscitate orders in patients with community-acquired pneumonia: a retrospective study.

Gertrud Baunbæk Egelund, Andreas Vestergaard Jensen, Pelle Trier Petersen, Stine Bang Andersen, Bjarne Ørskov Lindhardt, Gernot Rohde, Pernille Ravn, Christian von Plessen

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in BMC pulmonary medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Gertrud Baunbæk EgelundDepartment of Pulmonary and infectious medicine, Nordsjællands Hospital, Dyrehavevej 29, 3400, Hillerød, Denmark. gertrudbaknudsen@gmail.com.ORCID http://orcid.org/0000-0002-6653-1248
Andreas Vestergaard JensenDepartment of Pulmonary and infectious medicine, Nordsjællands Hospital, Dyrehavevej 29, 3400, Hillerød, Denmark. Andreas.vestergaard.jensen.01@regionh.dk.
Pelle Trier PetersenDepartment of Pulmonary and infectious medicine, Nordsjællands Hospital, Dyrehavevej 29, 3400, Hillerød, Denmark.
Stine Bang AndersenDepartment of Pulmonary and infectious medicine, Nordsjællands Hospital, Dyrehavevej 29, 3400, Hillerød, Denmark.
Bjarne Ørskov LindhardtUniversity of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
Gernot RohdeCAPNETZ-Stiftung, Hannover Medical School, Hanover, Germany.
Pernille RavnUniversity of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
Christian von PlessenInstitute for Clinical research University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark.
University of Copenhagen · DKNordsjællands Hospital · DKGoethe University Frankfurt · DEUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the use of do-not-resuscitate (DNR) orders in patients hospitalized with community-acquired pneumonia (CAP) and the association with mortality.

methodsWe assembled a cohort of 1317 adults hospitalized with radiographically confirmed CAP in three Danish hospitals. Patients were grouped into no DNR order, early DNR order (≤48 h after admission), and late DNR order (> 48 h after admission). We tested for associations between a DNR order and mortality using a cox proportional hazard model adjusted for patient and disease related factors.

resultsAmong 1317 patients 177 (13%) patients received a DNR order: 107 (8%) early and 70 (5%) late, during admission. Patients with a DNR order were older (82 years vs. 70 years, p < 0.001), more frequently nursing home residents (41% vs. 6%, p < 0.001) and had more comorbidities (one or more comorbidities: 73% vs. 59%, p < 0.001). The 30-day mortality was 62% and 4% in patients with and without a DNR order, respectively. DNR orders were associated with increased risk of 30-day mortality after adjustment for age, nursing home residency and comorbidities. The association was modified by the CURB-65 score Hazard ratio (HR) 39.3 (95% CI 13.9-110.6), HR 24.0 (95% CI 11.9-48,3) and HR 9.4 (95% CI: 4.7-18.6) for CURB-65 score 0-1, 2 and 3-5, respectively.

conclusionIn this representative Danish cohort, 13% of patients hospitalized with CAP received a DNR order. DNR orders were associated with higher mortality after adjustment for clinical risk factors. Thus, we encourage researcher to take DNR orders into account as potential confounder when reporting CAP associated mortality.

Indexed as

Resuscitation OrdersAgedAged, 80 and overCommunity-Acquired InfectionsComorbidityDenmarkFemaleHospital MortalityHumansMalePneumoniaProportional Hazards ModelsRetrospective StudiesRiskTime FactorsTreatment OutcomeCommunity-acquired pneumoniaDo not resuscitate ordersMortality

Identifiers

PMID32709220
PMCPMC7379759
OpenAlexW3045005105

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.