Evidence map›Paper›PMID 32709084›Full record

ArticleJournal of clinical medicine2020

Quantitative Evaluation of Meniscal Healing Process of Degenerative Meniscus Lesions Treated with Hyaluronic Acid: A Clinical and MRI Study.

Alessandra Berton, Umile Giuseppe Longo, Vincenzo Candela, Federico Greco, Francesca Maria Martina, Carlo Cosimo Quattrocchi, Vincenzo Denaro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Meniscal Tear Repair: What's New in the Literature?Translational sports medicine · 2025
    Review
  7. Advances in hyaluronic acid hydrogel for meniscus repair.Frontiers in bioengineering and biotechnology · 2025
    Review
  8. Article
  9. Molecular Biology of Meniscal Healing: A Narrative Review.International journal of molecular sciences · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alessandra BertonOrthopaedic and Trauma Surgery Unit, Campus Bio-Medico University, 00128 Rome, Italy.
Umile Giuseppe LongoOrthopaedic and Trauma Surgery Unit, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0003-4063-9821
Vincenzo CandelaOrthopaedic and Trauma Surgery Unit, Campus Bio-Medico University, 00128 Rome, Italy.
Federico GrecoRadiology Unit, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
Francesca Maria MartinaRadiology Unit, Campus Bio-Medico University of Rome, 00128 Rome, Italy.ORCID 0000-0003-1937-3272
Carlo Cosimo QuattrocchiRadiology Unit, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
Vincenzo DenaroOrthopaedic and Trauma Surgery Unit, Campus Bio-Medico University, 00128 Rome, Italy.
Università Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to evaluate clinical efficacy and healing effects of conservative management of degenerative meniscus lesions (DMLs) with a hyaluronic acid (HA) hydrogel.

methodsPatients were subjected to two HA injections two weeks apart. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Patient's Global Assessment (PtGA) and Clinical Observer Global Assessment (CoGA) of the disease were assessed at baseline, 30, and 60 days after treatment. Short Form (36) Health Survey (SF-36) was assessed at baseline and 60 days after treatment. One year after treatment, patients were called to know whether any of them had undergone arthroscopic partial meniscectomy (APM). All patients underwent magnetic resonance imaging using a 1.5-T Magnetic Resonance Imaging (MRI) scanner (Siemens Aera), which included a T2 mapping pulse sequence with multiple echoes at baseline and 60 days after treatment.

results40 patients were enrolled. WOMAC score, physical function subscale, PtGA and CoGA, and SF-36 showed a statistically significant difference between baseline and follow-up. One year after treatment, only one patient had undergone APM. A decrease in the T2 measurement was detected in the posterior horn medial meniscus in 39% of cases in both the red and red-white zone, and in 60% of cases in the white zone; in the posterior horn lateral meniscus in 55% of cases in both the red and white zones, and in 65% of cases in the red-white zone. Only for the latter, there was a statistically significant difference between baseline and posttreatment T2 measurements.

conclusionThis study supports the use of HA in the conservative management of DML as it is clinically effective and enhances meniscus healing as demonstrated by T2 measurements. Moreover, it reduces the need for APM at 1-year follow-up.

Indexed as

conservative managementdegenerative meniscus lesionhyaluronic acidmeniscal healingT2 mapping

Identifiers

PMID32709084
PMCPMC7408658
OpenAlexW3043322812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.