Evidence map›Paper›PMID 32709076›Full record

ArticlePharmaceutics2020

Antimicrobial Essential Oil Formulation: Chitosan Coated Nanoemulsions for Nose to Brain Delivery.

Federica Rinaldi, Alessandra Oliva, Manuela Sabatino, Anna Imbriano, Patrizia N Hanieh, Stefania Garzoli, Claudio M Mastroianni, Massimiliano De Angelis, Maria Claudia Miele, Marcela Arnaut and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Intranasal essential oils in therapy: advances in clinical applications and delivery mechanisms.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
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  11. The synergistic effect ofFrontiers in pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Federica RinaldiDepartment of Drug Chemistry and Technology, Sapienza University of Rome, 00185 Rome, Italy.
Alessandra OlivaDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0832-7975
Manuela SabatinoDepartment of Drug Chemistry and Technology, Rome Center for Molecular Design, 00185 Rome, Italy.
Anna ImbrianoDepartment of Drug Chemistry and Technology, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-2375-6655
Patrizia N HaniehDepartment of Drug Chemistry and Technology, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-3278-8376
Stefania GarzoliDepartment of Drug Chemistry and Technology, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-8535-0533
Claudio M MastroianniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-1286-467X
Massimiliano De AngelisDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Maria Claudia MieleDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Marcela ArnautDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Federica Di TimoteoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Carlotta MarianecciDepartment of Drug Chemistry and Technology, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-2505-1766
Rino RagnoDepartment of Drug Chemistry and Technology, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-5399-975X
Maria CarafaDepartment of Drug Chemistry and Technology, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-3968-3385
Sapienza University of Rome · ITRome International Center for Materials Science · IT

Funding

Sapienza Università di Roma Ateneo 2019 (prot. RM11916B8876093E) (Ateneo 2018 prot. RM118164361B425B)
6 · The paper itself

Abstract

Brain infections as meningitis and encephalitis are attracting a great interest. Challenges in the treatment of these diseases are mainly represented by the blood brain barrier (BBB) that impairs the efficient delivery of even very potent drugs to reach the brain. The nose to the brain administration route, is a non-invasive alternative for a quick onset of action, and enables the transport of numerous medicinal agents straight to the brain thus workarounding the BBB through the highly vascularized olfactory region. In this report,

Indexed as

antibacterial activitychitosan coatingessential oilsnanoemulsionsnose to brain deliverySyzygium aromaticumThymus vulgaris

Identifiers

PMID32709076
PMCPMC7407154
OpenAlexW3043496240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.