Evidence map›Paper›PMID 32709042›Full record

ArticleCells2020

The Distribution of Circulating Tumor Cells Is Different in Metastatic Lobular Compared to Ductal Carcinoma of the Breast-Long-Term Prognostic Significance.

Ulrik Narbe, Pär-Ola Bendahl, Kristina Aaltonen, Mårten Fernö, Carina Forsare, Charlotte Levin Tykjær Jørgensen, Anna-Maria Larsson, Lisa Rydén

Registry-linked trialOpen access · goldAbstract readComparative Study
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01322893 (Enumeration and Molecular Characterization of Circulating Tumour Cells in Women With Metastatic Breast Cancer), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01322893 completednot on this map

Enumeration and Molecular Characterization of Circulating Tumour Cells in Women With Metastatic Breast Cancer

TypeobservationalSponsorLund University HospitalRan2011 to 2016Enrolled150ConditionsMetastatic Breast Cancer
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ulrik NarbeDepartment of Clinical Sciences, Division of Oncology, Lund University, SE-223 81 Lund, Sweden.ORCID 0000-0002-7062-6581
Pär-Ola BendahlDepartment of Clinical Sciences, Division of Oncology, Lund University, SE-223 81 Lund, Sweden.
Kristina AaltonenDepartment of Laboratory Medicine, Division of Translational Cancer Research, Lund University, SE-223 81 Lund, Sweden.
Mårten FernöDepartment of Clinical Sciences, Division of Oncology, Lund University, SE-223 81 Lund, Sweden.
Carina ForsareDepartment of Clinical Sciences, Division of Oncology, Lund University, SE-223 81 Lund, Sweden.
Charlotte Levin Tykjær JørgensenDepartment of Clinical Sciences, Division of Oncology, Lund University, SE-223 81 Lund, Sweden.
Anna-Maria LarssonDepartment of Clinical Sciences, Division of Oncology, Lund University, SE-223 81 Lund, Sweden.
Lisa RydénDepartment of Clinical Sciences, Division of Surgery, Lund University, SE-223 81 Lund, Sweden.ORCID 0000-0001-7515-3130
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInvasive lobular carcinoma (ILC) has distinguishing features when compared to invasive ductal carcinoma of no special type (NST). In this study, we explored the distributional and prognostic characteristics of circulating tumor cells (CTCs) in metastatic ILC and NST. MATERIALS AND

methodsPatients were included in an observational trial (ClinicalTrials.gov NCT01322893) with ILC (

resultsThe CTC counts were higher in ILC (median 70) than in NST cases (median 2) at baseline (

conclusionsThe number of CTCs is higher in ILC than in NST, implying that a higher CTC cut-off could be considered for ILC when applying the CellSearch technique.

Indexed as

AgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularCell CountDisease ProgressionFemaleHumansKaplan-Meier EstimateMiddle AgedMucin-1Neoplasm MetastasisNeoplastic Cells, CirculatingPrognosisProgression-Free SurvivalMUC1 protein, humanMucin-1cancer antigen 15-3circulating tumor cellsCTC clusterinvasive ductal carcinoma of no special typeinvasive lobular carcinoma

Identifiers

PMID32709042
PMCPMC7407940
OpenAlexW3042374185

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.