ArticleInternational journal of molecular sciences2020
Sperm Motility of Mice under Simulated Microgravity and Hypergravity.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Simulated microgravity alters sperm navigation, fertilization and embryo development in mammals.Communications biology · 2026Article
- Oxidative Damage Under Microgravity Conditions: Response Mechanisms, Monitoring Methods and Countermeasures on Somatic and Germ Cells.International journal of molecular sciences · 2025Review
- The Motility of Mouse Spermatozoa Changes Differentially After 30-Minute Exposure Under Simulating Weightlessness and Hypergravity.International journal of molecular sciences · 2024Article
- The Oxidative Phosphorylation and Cytoskeleton Proteins of Mouse Ovaries after 96 Hours of Hindlimb Suspension.Life (Basel, Switzerland) · 2023Article
- Article
- The importance of gravity vector on adult mammalian organisms: Effects of hypergravity on mouse testis.PloS one · 2023Article
- Single Cell in a Gravity Field.Life (Basel, Switzerland) · 2022Review
- Sperm of Fruit FlyInternational journal of molecular sciences · 2022Article
- Effects of space flight on sperm function and integrity: A systematic review.Frontiers in physiology · 2022Review
- State ofInternational journal of molecular sciences · 2021Article
- Mouse and Fly Sperm Motility Changes Differently under Modelling Microgravity.Current issues in molecular biology · 2021Article
- Microgravity and Space Medicine.International journal of molecular sciences · 2021Article
- Mitochondrial Respiration inCurrent issues in molecular biology · 2021Article
- Hypergravity Load Modulates Acetaminophen Nephrotoxicity via Endoplasmic Reticulum Stress in Association with Hepatic microRNA-122 Expression.International journal of molecular sciences · 2021Article
- Relative Biological Effectiveness of High LET Particles on the Reproductive System and Fetal Development.Life (Basel, Switzerland) · 2020Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
For deep space exploration, reproductive health must be maintained to preserve the species. However, the mechanisms underlying the effect of changes in gravity on male germ cells remain poorly understood. The aim of this study was to determine the effect of simulated micro- and hypergravity on mouse sperm motility and the mechanisms of this change. For 1, 3 and 6 h, mouse sperm samples isolated from the caudal epididymis were subjected to simulated microgravity using a random position machine and 2g hypergravity using a centrifuge. The experimental samples were compared with static and dynamic controls. The sperm motility and the percentage of motile sperm were determined using microscopy and video analysis, cell respiration was determined by polarography, the protein content was assessed by Western blotting and the mRNA levels were determined using qRT-PCR. The results indicated that hypergravity conditions led to more significant changes than simulated microgravity conditions: after 1 h, the speed of sperm movement decreased, and after 3 h, the number of motile cells began to decrease. Under the microgravity model, the speed of movement did not change, but the motile spermatozoa decreased after 6 h of exposure. These changes are likely associated with a change in the structure of the microtubule cytoskeleton, and changes in the energy supply are an adaptive reaction to changes in sperm motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.