Evidence map›Paper›PMID 32708832›Full record

ArticleInternational journal of molecular sciences2020

Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association.

Tatiana A Chernova, Zhen Yang, Tatiana S Karpova, John R Shanks, Natalia Shcherbik, Keith D Wilkinson, Yury O Chernoff

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Tatiana A ChernovaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0003-1966-0159
Zhen YangDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
Tatiana S KarpovaCenter for Cancer Research Core Fluorescence Imaging Facility, Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
John R ShanksDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
Natalia ShcherbikDepartment of Cell Biology, Rowan University, School of Osteopathic Medicine, Stratford, NJ 08084, USA.
Keith D WilkinsonDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
Yury O ChernoffSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332-2000, USA.ORCID 0000-0002-8934-9051
Emory University · USGeorgia Institute of Technology · USNational Institutes of Health · USRowan University · US

Funding

Translational Rescue Mechanisms in EukaryotesR01GM114308 · NIGMS · ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED · PI SHCHERBIK, NATALIA · 2016 to 2020
$1.6M
Ubiquitin and regulation of prion induction by a short-lived proteinR01GM093294 · NIGMS · EMORY UNIVERSITY · PI WILKINSON, KEITH D · 2011 to 2014
$1.3M
National Science Foundation MCB 1817976NIGMS NIH HHS R01 GM114308NIH HHS R01GM093294NIH HHS R01GM114308
6 · The paper itself

Abstract

Yeast prions and mnemons are respectively transmissible and non-transmissible self-perpetuating protein assemblies, frequently based on cross-β ordered detergent-resistant aggregates (amyloids). Prions cause devastating diseases in mammals and control heritable traits in yeast. It was shown that the de novo formation of the prion form [

Indexed as

Protein AggregatesCell MembraneGTP-Binding Protein gamma SubunitsPeptide Termination FactorsProteolysisSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsUbiquitinationGTP-Binding Protein gamma SubunitsPeptide Termination FactorsProtein AggregatesSaccharomyces cerevisiae ProteinsSTE18 protein, S cerevisiaeSUP35 protein, S cerevisiaeamyloidG-proteinmatingmnemonphosphorylationprionSte18Sup35ubiquitinyeast

Identifiers

PMID32708832
PMCPMC7403958
OpenAlexW3043591404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.