Evidence map›Paper›PMID 32708812›Full record

ArticleCancers2020

Lectins in Cervical Screening.

Anita Ww Lim, André A Neves, Sarah Lam Shang Leen, Pierre Lao-Sirieix, Elizabeth Bird-Lieberman, Naveena Singh, Michael Sheaff, Tony Hollingworth, Kevin Brindle, Peter Sasieni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Anita Ww LimWolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.ORCID 0000-0002-4407-7451
André A NevesCancer Research UK Cambridge Institute, Li-Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK.
Sarah Lam Shang LeenDepartment of Cellular Pathology, Barts and the London NHS Trust, Pathology and Pharmacy Building, The Royal London Hospital, 80 Newark Street, London E1 2ES, UK.
Pierre Lao-SirieixMRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK.
Elizabeth Bird-LiebermanMRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK.
Naveena SinghDepartment of Cellular Pathology, Barts and the London NHS Trust, Pathology and Pharmacy Building, The Royal London Hospital, 80 Newark Street, London E1 2ES, UK.
Michael SheaffDepartment of Cellular Pathology, Barts and the London NHS Trust, Pathology and Pharmacy Building, The Royal London Hospital, 80 Newark Street, London E1 2ES, UK.ORCID 0000-0001-9189-0181
Tony HollingworthWhipps Cross University Hospital, Barts Health NHS Trust, Whipps Cross Road, London E11 1NR, UK.
Kevin BrindleCancer Research UK Cambridge Institute, Li-Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK.
Peter SasieniWolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Royal London Hospital · GBQueen Mary University of London · GBUniversity of Cambridge · GBBarts Health NHS Trust · GBJohn Radcliffe Hospital · GBMRC Cancer Unit · GB

Funding

Cancer Research UK 16892Cancer Research UK 17242Cancer Research UK 27047Cancer Research UK 28289Cancer Research UK C197/A28289Cancer Research UK C8162/A16892Cancer Research UK C8162/A27047
6 · The paper itself

Abstract

Cervical screening in low-resource settings remains an unmet need. Lectins are naturally occurring sugar-binding glycoproteins whose binding patterns change as cancer develops. Lectins discriminate between dysplasia and normal tissue in several precancerous conditions. We explored whether lectins could be developed for cervical screening via visual inspection. Discovery work comprised lectin histochemistry using a panel of candidate lectins on fixed-human cervix tissue (high-grade cervical intraepithelial neoplasia (CIN3,

Indexed as

cervical cancerglycanslectinsscreening

Identifiers

PMID32708812
PMCPMC7409129
OpenAlexW3043074709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.