Evidence map›Paper›PMID 32708724›Full record

ArticleJournal of clinical medicine2020

Chronoradiation Therapy for Prostate Cancer: Morning Proton Beam Therapy Ameliorates Worsening Lower Urinary Tract Symptoms.

Hiromitsu Negoro, Takashi Iizumi, Yutaro Mori, Yoshitaka Matsumoto, Ichiro Chihara, Akio Hoshi, Hideyuki Sakurai, Hiroyuki Nishiyama, Hitoshi Ishikawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hiromitsu NegoroDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-3575, Japan.ORCID 0000-0003-1144-2755
Takashi IizumiDepartment of Radiation Oncology, University of Tsukuba, Ibaraki 305-8575, Japan.
Yutaro MoriDepartment of Radiation Oncology, University of Tsukuba, Ibaraki 305-8575, Japan.
Yoshitaka MatsumotoDepartment of Radiation Oncology, University of Tsukuba, Ibaraki 305-8575, Japan.
Ichiro ChiharaDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-3575, Japan.
Akio HoshiDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-3575, Japan.
Hideyuki SakuraiDepartment of Radiation Oncology, University of Tsukuba, Ibaraki 305-8575, Japan.
Hiroyuki NishiyamaDepartment of Urology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-3575, Japan.
Hitoshi IshikawaDepartment of Radiation Oncology, University of Tsukuba, Ibaraki 305-8575, Japan.ORCID 0000-0002-0046-9787
University of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeWorsening lower urinary tract symptoms (LUTS) are a frequent adverse event following proton beam therapy (PBT) for localized prostate cancer. We investigated the differences in worsening LUTS among patients who received PBT at different times of day. PARTICIPANTS AND

methodsAmong 173 patients who underwent PBT for prostate cancer, 168 patients (median age 68.5 years) completed international prostate symptom score (IPSS) questionnaires and were included. Changes in the IPSS from baseline to the end of PBT were assessed by multiple linear regression analysis for age, National Comprehensive Cancer Network risk classification, androgen deprivation therapy, fractional PBT dose, clinical target volume, severity of IPSS, diabetes, LUTS medication use before PBT, anti-coagulant therapy and radiation time of day (morning (08:30-10:30), around noon (10:31-14:30), and late afternoon (14:31-16:30)).

resultsIPSS total score and IPSS-Quality of Life (QoL) score (12 patients were excluded due to missing IPSS-QoL score) increased from eight to 14.9 (

conclusionsMorning PBT for localized prostate cancer significantly ameliorated worsening LUTS and improved QoL compared with treatment around noon or late afternoon. Chronoradiation therapy for localized prostate cancer may be effective and further research to elucidate the underlying mechanism is warranted.

Indexed as

circadianLUTSradiationtiming

Identifiers

PMID32708724
PMCPMC7408763
OpenAlexW3043720106

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.