Evidence map›Paper›PMID 32708700›Full record

ArticleViruses2020

Genotypic Characterization of Epstein Barr Virus in Blood of Patients with Suspected Nasopharyngeal Carcinoma in Ghana.

Richmond Ayee, Maame Ekua Oforiwaa Ofori, Emmanuel Ayitey Tagoe, Sylvester Languon, Kafui Searyoh, Louis Armooh, Estella Bilson-Amoah, Kenneth Baidoo, Emmanuel Kitcher, Edward Wright and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Richmond AyeeWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Accra 00233, Ghana.
Maame Ekua Oforiwaa OforiWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Accra 00233, Ghana.
Emmanuel Ayitey TagoeWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Accra 00233, Ghana.
Sylvester LanguonWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Accra 00233, Ghana.ORCID 0000-0001-9924-9006
Kafui SearyohEar, Nose and Throat Unit, Korle-Bu Teaching Hospital, Accra 00233, Ghana.
Louis ArmoohEar, Nose and Throat Unit, Korle-Bu Teaching Hospital, Accra 00233, Ghana.
Estella Bilson-AmoahEar, Nose and Throat Unit, Korle-Bu Teaching Hospital, Accra 00233, Ghana.
Kenneth BaidooEar, Nose and Throat Unit, Korle-Bu Teaching Hospital, Accra 00233, Ghana.
Emmanuel KitcherEar, Nose and Throat Unit, Korle-Bu Teaching Hospital, Accra 00233, Ghana.
Edward WrightSchool of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.ORCID 0000-0001-7041-5138
Osbourne QuayeWest African Center for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Accra 00233, Ghana.ORCID 0000-0002-0621-876X
Korle Bu Teaching Hospital · GHUniversity of Ghana · GHUniversity of Sussex · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasopharyngeal cancer (NPC) is associated with Epstein Barr virus (EBV) infection. However different viral strains have been implicated in NPC worldwide. This study aimed to detect and characterize EBV in patients diagnosed with NPC in Ghana. A total of 55 patients diagnosed with NPC by CT scan and endoscopy were age-matched with 53 controls without a known oncological disease. Venous blood was collected from the study participants and DNA extracted from the blood samples. Detection of EBV and genotyping were done by amplifying Epstein Barr nuclear antigen 1 (EBNA-1) and Epstein Barr nuclear antigen 2 (EBNA-2), respectively, using specific primers. Viral load in patients and controls was determined using real-time polymerase chain reaction. EBV positivity in controls (92%) was significantly greater than that of NPC patients (67%) (χ2 = 19.17,

Indexed as

AdultCase-Control StudiesDNA, ViralEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFemaleGenotyping TechniquesGhanaHerpesvirus 4, HumanHumansMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsPolymerase Chain ReactionReal-Time Polymerase Chain ReactionDNA, ViralEBNA-2 protein, Human herpesvirus 4EBV-encoded nuclear antigen 1Epstein-Barr Virus Nuclear AntigensViral ProteinsEpstein Barr virusgenotypesGhananasopharyngeal cancerviral load

Identifiers

PMID32708700
PMCPMC7412455
OpenAlexW3043762594

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.