ReviewInternational journal of molecular sciences2020
Egg Allergy: Diagnosis and Immunotherapy.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 92 citations in OpenAlex.
- Who fails the egg ladder? Predictors of reactions and clinical outcomes with individualized entry-step selection in 197 children with IgE-mediated egg allergy.European journal of pediatrics · 2026Article
- Novel food processing technologies to reduce egg allergenicity: a review from allergen digestion to IgE-mediated responses.Food science of animal resources · 2026Review
- Comprehensive allergen screening and semi-quantification in plant based Milk alternatives by mass spectrometry.Food chemistry: X · 2026Article
- Anaphylaxis to duck and goose eggs with preserved tolerance to hen's eggs: A case report.Allergologie select · 2026Article
- Bioactive compound ginkgolide B alleviates food allergy by regulating mTOR signaling pathway.Frontiers in immunology · 2026Article
- Profound Impact of Local Climatic Conditions on IgE Sensitization Profiles: Evidence from Argentine Cities.International journal of molecular sciences · 2025Article
- Exercise-induced anaphylaxis triggered by bird-egg syndrome: unraveling the link between egg yolk and bird allergens.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Article
- Development and Evaluation of Egg-Free Mayonnaise Stabilized with Aquafaba and Gum Tragacanth: Functional, Sensory, and Storage Properties.Molecules (Basel, Switzerland) · 2025Article
- Global Burden of Allergies: Mechanisms of Development, Challenges in Diagnosis, and Treatment.Life (Basel, Switzerland) · 2025Review
- Global Perspectives on Allergen Labeling: Harmonization of Regulations and Practices.Allergy, asthma & immunology research · 2025Review
- Unravelling the pathogenesis of Eosinophilic Esophagitis from genetic predisposition to environmental triggers.Clinical and experimental immunology · 2025Review
- Baked Egg Oral Immunotherapy: Current State in Pediatric Age.Nutrients · 2024Review
- Ovalbumin promotes innate immune response of Caenorhabditis elegans through DAF-16 and SKN-1 pathways in insulin/IGF-1 signaling.Journal of physiology and biochemistry · 2024Article
- Advances in Understanding the Antioxidant and Antigenic Properties of Egg-Derived Peptides.Molecules (Basel, Switzerland) · 2024Article
- Hen's egg ladder: Therapy option for the gradual introduction of hen's eggs in cases of hen's egg allergy.Allergologie select · 2024Review
- Methodological Principles of Nasal Food Challenge.Nutrients · 2023Article
- Oral and nasal provocation test in chicken egg allergy-case report.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Proteomic investigation and understanding on IgY purification and product development.Poultry science · 2023Article
- Advanced Proteomic and Bioinformatic Tools for Predictive Analysis of Allergens in Novel Foods.Biology · 2023Review
- The Impact of Processing and Extraction Methods on the Allergenicity of Targeted Protein Quantification as Well as Bioactive Peptides Derived from Egg.Molecules (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypersensitivity or an allergy to chicken egg proteins is a predominant symptomatic condition affecting 1 in 20 children in Australia; however, an effective form of therapy has not yet been found. This occurs as the immune system of the allergic individual overreacts when in contact with egg allergens (egg proteins), triggering a complex immune response. The subsequent instantaneous inflammatory immune response is characterized by the excessive production of immunoglobulin E (IgE) antibody against the allergen, T-cell mediators and inflammation. Current allergen-specific approaches to egg allergy diagnosis and treatment lack consistency and therefore pose safety concerns among anaphylactic patients. Immunotherapy has thus far been found to be the most efficient way to treat and relieve symptoms, this includes oral immunotherapy (OIT) and sublingual immunotherapy (SLIT). A major limitation in immunotherapy, however, is the difficulty in preparing effective and safe extracts from natural allergen sources. Advances in molecular techniques allow for the production of safe and standardized recombinant and hypoallergenic egg variants by targeting the IgE-binding epitopes responsible for clinical allergic symptoms. Site-directed mutagenesis can be performed to create such safe hypoallergens for their potential use in future methods of immunotherapy, providing a feasible standardized therapeutic approach to target egg allergies safely.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.