ArticleDiagnostics (Basel, Switzerland)2020
Validation of the Use of Automated and Manual Quantitative Analysis of Corneal Nerve Plexus Following Refractive Surgery.
Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Noncontact Esthesiometer: Large Cohort Study on Agreement with Contact Method and Correlations with Corneal Nerves and Ocular Surface.Ophthalmology science · 2026Article
- Article
- Applications of Artificial Intelligence in Corneal Nerve Images in Ophthalmology.Diagnostics (Basel, Switzerland) · 2026Review
- The Association among Corneal Nerve Metrics, Ocular Surface Integrity, and Renal Function in Type 2 Diabetes.Ophthalmology science · 2026Article
- Evaluation of Corneal Sensitivity: Tools We Have.Diagnostics (Basel, Switzerland) · 2025Review
- Corneal Nerve Morphology in Painful Diabetic Neuropathy: A Meta-Analysis of In Vivo Confocal Microscopy Studies.Biomedicines · 2025Review
- Neuropathic corneal pain following refractive surgery: risk factors, clinical manifestations, imaging and proteomic characteristics.The British journal of ophthalmology · 2025Article
- Bilateral In Vivo Confocal Microscopic Changes of the Corneal Subbasal Nerve Plexus in Patients with Acute Herpes Zoster Ophthalmicus.Ophthalmology and therapy · 2025Article
- Obesity negatively impacts corneal nerves in patients with diabetes mellitus.Eye and vision (London, England) · 2025Article
- Randomized controlled trial on corneal denervation, neuroinflammation and ocular surface in corneal lenticule extraction for advanced refractive correction (CLEAR) and small incision lenticule extraction (SMILE).Eye and vision (London, England) · 2025Article
- Differential Impact of Metabolic Factors and Comorbidities on Peripheral Neuropathy.Journal of the peripheral nervous system : JPNS · 2025Article
- Impact of corneal sub-basal nerve plexus on epithelial thickness after small incision lenticule extraction (SMILE): a quantitative assessment using in vivo confocal microscopy and optical coherence tomography.Quantitative imaging in medicine and surgery · 2025Article
- Ethnic and sex differences in corneal nerves and corneal epithelial cells in healthy population.Frontiers in medicine · 2025Article
- Diabetic corneal neuropathy and its relation to the severity of retinopathy in patients with type 2 diabetes mellitus: an in vivo confocal microscopy study.International ophthalmology · 2024Article
- Neuropathic Corneal Pain after Coronavirus Disease 2019 (COVID-19) Infection.Diseases (Basel, Switzerland) · 2024Article
- Clinical associations of corneal neuromas with ocular surface diseases.Neural regeneration research · 2024Review
- Oral Peroxisome Proliferator-Activated Receptor-α Agonist Enhances Corneal Nerve Regeneration in Patients With Type 2 Diabetes.Diabetes · 2023Article
- Corneal dendritic cells in diabetes mellitus: A narrative review.Frontiers in endocrinology · 2023Review
- Artificial Intelligence and Corneal Confocal Microscopy: The Start of a Beautiful Relationship.Journal of clinical medicine · 2022Review
- Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy.Neural regeneration research · 2022Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following refractive surgery, the cornea is denervated and re-innervated, hence a reproducible tool to objectively quantify this change is warranted. This study aimed to determine the repeatability and reproducibility of corneal nerve quantification between automated (ACCMetrics) and manual software (CCMetrics) following refractive surgery. A total of 1007 in vivo confocal microscopy images from 20 post-small incision lenticule extraction (SMILE) or post-laser-assisted in situ keratomileusis (LASIK) patients were evaluated by two independent observers using CCMetrics for corneal nerve fibre density (CNFD), corneal nerve branch density (CNBD), and corneal nerve fibre length (CNFL). Intra-observer and inter-observer reproducibility and repeatability, as well as agreement and correlation between the measurements obtained by ACCMetrics and CCMetrics, were assessed. We found that CNFL demonstrated the best intra- and inter-observer agreement followed by CNFD (intra-class correlation coefficient (ICC) = 0.799 and 0.740, respectively for CNFL; 0.757 and 0.728 for CNFD). CNBD demonstrated poorest intra- and inter-observer ICC. There was an underestimation in ACCMetrics measurements compared to CCMetrics measurements, although the differences were not significant. Our data suggested that both automated and manual methods can be used as reliable tools for the evaluation of corneal nerve status following refractive surgery. However, the measurements obtained with different methods are not interchangeable.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.