SynthesisNutrients2020
Choline: An Essential Nutrient for Skeletal Muscle.
Synthesis in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- The Potential Role of Polyphenols in Modulating Mitochondrial Bioenergetics within the Skeletal Muscle: A Systematic Review of Preclinical Models.Molecules (Basel, Switzerland) · 2021Pooled it
- Pilot Randomized Controlled Trial of Krill Oil Supplementation for Chronic Musculoskeletal Pain in Older Adults.The Journal of nutrition · 2026Trial
- Effects of branched chain amino acids, l-citrulline, and alpha-glycerylphosphorylcholine supplementation on exercise performance in trained cyclists: a randomized crossover trial.Journal of the International Society of Sports Nutrition · 2023Trial
- Serum metabolomic profiling reveals load-specific adaptations to resistance training.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Combined in ovo and post-hatch choline supplementation enhances growth and muscle development in goslings.Poultry science · 2026Article
- Krill Oil for Pain in Elders: protocol for a pilot, double-blind, randomised controlled trial to evaluate the efficacy of 4 g/d krill oil supplementation for chronic musculoskeletal pain and mobility limitations in older adults.The British journal of nutrition · 2026Article
- Genome-wide association study of mature cow size traits in American Angus cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Methods of Engaging Interest-Holders in Healthcare Evidence Syntheses: A Scoping Review.Cochrane evidence synthesis and methods · 2026Review
- Nano-functionalized probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis.Nature communications · 2025Article
- Transgenerational effects of in ovo stimulation with synbiotic and choline on gonadal tissue across three generations.Scientific reports · 2025Article
- Association of Dietary Choline Intake With Incidence of Frailty: A Nationwide Prospective Cohort Study From China.Journal of cachexia, sarcopenia and muscle · 2025Article
- Effects of Long-Chain n-3 Fatty Acids Supplementation During Caloric Restriction on Body Composition in Overweight and Obese Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Food science & nutrition · 2025Review
- Mesotherapy with HA and Choline Against Facial Skin Aging: An Open-Label Uncontrolled, Monocentric Study.Journal of clinical medicine · 2025Article
- Choline Oxidase-Incorporated ATRP-Based Cerium Nanogels as Nanozymes for Colorimetric Detection of Hydrogen Peroxide and Choline.Biosensors · 2024Article
- Growth Performance, Blood Metabolites, Carcass Characteristics and Meat Quality of Lambs Fed Diets Containing Different Energy Levels Supplemented with Rumen-Protected Choline.Animals : an open access journal from MDPI · 2024Article
- Article
- Radiopharmaceuticals for Skeletal Muscle PET Imaging.International journal of molecular sciences · 2024Review
- Cross-sectional analysis of healthy individuals across decades: Aging signatures across multiple physiological compartments.Aging cell · 2024Article
- Evolutionary Adaptation of Protein Turnover in White Muscle of Stenothermal Antarctic Fish: Elevated Cold Compensation at Reduced Thermal Responsiveness.Biomolecules · 2023Article
- Circulating direct infusion MS and NMR metabolomic profiles of post-gonadectomy kittens with or without additional dietary choline supplementation.The British journal of nutrition · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCholine is an essential micronutrient with a pivotal role in several metabolic pathways contributing to liver, neurological, and hematological homeostasis. Although choline is commonly administered to improve physical performance, its effects on muscle are still unclear. The aim of this scoping review is to analyze the role of choline on skeletal muscle in terms of biological effects and clinical implications.
methodsA technical expert panel (TEP) of 6 medical specialists with expertise in muscle physiology and skeletal muscle disorders performed the review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP planned a research on PubMed selecting "choline" as MeSH (Medical Subject Headings) term adding to PubMed Search Builder the terms "skeletal muscle" and "muscle striated". TEP considered for eligibility articles published in the last 30 years, including original researches, particularly in vitro studies, and animal and clinical studies in the English language.
resultsFrom the 1239 studies identified, TEP included 14 studies, 3 in vitro, 9 animal, and 2 clinical studies.
conclusionsOur scoping review elucidates and summarizes the crucial role of choline in modulating muscle fat metabolism, muscle proteins homeostasis, and the modulation of inflammation and autophagy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.