Evidence map›Paper›PMID 32708426›Full record

ArticleInternational journal of molecular sciences2020

A Novel Synthetic Compound (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile Inhibits TNFα-Induced

Munki Jeong, Euitaek Jung, Young Han Lee, Jeong Kon Seo, Seunghyun Ahn, Dongsoo Koh, Yoongho Lim, Soon Young Shin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. (IUCrData · 2023
    Article
  3. Total Synthesis of Lineaflavones A, C, D, and Analogues.Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Munki JeongDepartment of Biological Sciences, Sanghuh College of Lifesciences, Koknkuk University, Seoul 05029, Korea.
Euitaek JungDepartment of Biological Sciences, Sanghuh College of Lifesciences, Koknkuk University, Seoul 05029, Korea.
Young Han LeeDepartment of Biological Sciences, Sanghuh College of Lifesciences, Koknkuk University, Seoul 05029, Korea.ORCID 0000-0003-4060-6587
Jeong Kon SeoUNIST Central Research Facilities, Ulsan National Institute of Science and Technology, Ulsan 44919, Korea.
Seunghyun AhnDepartment of Applied Chemistry, Dongduk Women's University, Seoul 02748, Korea.
Dongsoo KohDepartment of Applied Chemistry, Dongduk Women's University, Seoul 02748, Korea.ORCID 0000-0001-8984-0273
Yoongho LimCancer and Metabolism Institute, Konkuk University, Seoul 05029, Korea.
Soon Young ShinDepartment of Biological Sciences, Sanghuh College of Lifesciences, Koknkuk University, Seoul 05029, Korea.ORCID 0000-0002-1075-0011
Konkuk University · KRDongduk Women's University · KRUlsan National Institute of Science and Technology · KR

Funding

National Research Foundation of Korea NRF-2019R1A2C1002677
6 · The paper itself

Abstract

Breast cancer is a common malignancy among women worldwide. Gelatinases such as matrix metallopeptidase 2 (MMP2) and MMP9 play crucial roles in cancer cell migration, invasion, and metastasis. To develop a novel platform compound, we synthesized a flavonoid derivative, (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile (named DK4023) and characterized its inhibitory effects on the motility and

Indexed as

ActinsAntineoplastic AgentsBreast NeoplasmsCell Line, TumorCell MovementCell SurvivalDown-RegulationEarly Growth Response Protein 1FemaleFlavonoidsHumansMAP Kinase Signaling SystemMatrix Metalloproteinase 2Matrix Metalloproteinase 9Neoplasm InvasivenessNF-kappa BActinsAntineoplastic AgentsEarly Growth Response Protein 1EGR1 protein, humanFlavonoidsMatrix Metalloproteinase 2Matrix Metalloproteinase 9MMP2 protein, humanMMP9 protein, humanNF-kappa BTumor Necrosis Factor-alpha(E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrileEGR-1flavonoidMDA-MB-231MMP9TNFα

Identifiers

PMID32708426
PMCPMC7404000
OpenAlexW3042783068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.