Evidence map›Paper›PMID 32708377›Full record

ReviewNutrients2020

To Wean or Not to Wean: The Role of Autologous Reconstructive Surgery in the Natural History of Pediatric Short Bowel Syndrome on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP).

Teresa Capriati, Antonella Mosca, Tommaso Alterio, Maria Immacolata Spagnuolo, Paolo Gandullia, Antonella Lezo, Paolo Lionetti, Lorenzo D'Antiga, Fabio Fusaro, Antonella Diamanti

Registry-linked trialAbstract readReview
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06904872 (A Phase 2, Placebo-Controlled, Randomized, Double-Blind Study of 2 Doses of Crofelemer for the Treatment of Adult Patients With Short Bowel Syndrome and Intestinal Failure), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06904872 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

A Phase 2, Placebo-Controlled, Randomized, Double-Blind Study of 2 Doses of Crofelemer for the Treatment of Adult Patients With Short Bowel Syndrome and Intestinal Failure (SBS-IF) Without Colon-in-continuity (CIC)

TypeinterventionalSponsorNapo Therapeutics, S.p.A.Ran2025 to 2027Enrolled18ConditionsShort Bowel Syndrome, Malabsorption Syndromes, Short Gut Syndrome, Post-Op ComplicationArmsCrofelemer Powder for Oral Solution, Matched Placebo Powder for Oral Solution
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Teresa CapriatiArtificial Nutrition Unit, Bambino Gesù Children Hospital, 00165 Rome, Italy.
Antonella MoscaHepatology Unit, Bambino Gesù Children Hospital, 00165 Rome, Italy.
Tommaso AlterioHepatology Unit, Bambino Gesù Children Hospital, 00165 Rome, Italy.ORCID 0000-0002-3082-855X
Maria Immacolata SpagnuoloDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80138 Naples, Italy.ORCID 0000-0001-5396-4944
Paolo GandulliaGastroenterology Unit, G.Gaslini Institute for Maternal and Child Health, IRCCS, 16145 Genova, Italy.
Antonella LezoDivision of Nutrition, Regina Margherita Children's Hospital, 10126 Turin, Italy.
Paolo LionettiDepartment of Neuroscience, Psychology, Pharmacology and Child's Health, University of Florence, Meyer Hospital, 50139 Florence, Italy.
Lorenzo D'AntigaPaediatric, Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, 24127 Bergamo, Italy.ORCID 0000-0001-7150-3148
Fabio FusaroDepartment of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital, 00165 Rome, Italy.
Antonella DiamantiArtificial Nutrition Unit, Bambino Gesù Children Hospital, 00165 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric Short Bowel Syndrome (SBS) can require prolonged parenteral nutrition (PN). Over the years, SBS management has been implemented by autologous gastrointestinal reconstructive surgery (AGIR). The primary objective of the present review was to assess the effect of AGIR on weaning off PN. We also evaluated how AGIR impacts survival, the need for transplantation (Tx) and the development of liver disease (LD). We conducted a systematic literature search to identify studies published from January 1999 to the present and 947 patients were identified. PN alone was weakly associated with higher probability of weaning from PN (OR = 1.1,

Indexed as

Parenteral NutritionPatient SelectionChildDigestive System Surgical ProceduresFemaleGastroenterologyHumansItalyLiver DiseasesMaleNutritional SciencesPlastic Surgery ProceduresPrevalenceShort Bowel SyndromeSocieties, MedicalSocieties, Scientificautologous gastrointestinal reconstructive surgeryintestinal failureliver diseaseparenteral nutritionshort bowel syndrome

Identifiers

PMID32708377
PMCPMC7400841

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.