ReviewInternational journal of molecular sciences2020
Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 8 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- MMP-9 as a diagnostic salivary biomarker for early detection of oral cancers: systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Increased of IL-18 levels are associated with periodontitis: a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- Potential noninvasive biomarkers for the malignant transformation of oral leukoplakia: A systematic review and meta-analysis.Cancer medicine · 2023Pooled it
- Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease.Frontiers in bioengineering and biotechnology · 2023Pooled it
- Does oral lichen planus aggravate the state of periodontal disease? A systematic review and meta-analysis.Clinical oral investigations · 2022Pooled it
- Salivary Cytokines as Biomarkers for Oral Squamous Cell Carcinoma: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Changes in Inflammatory Cytokines in Saliva after Non-Surgical Periodontal Therapy: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Clinical Features Associated With Periodontal Case Misclassification by an Active Matrix Metalloproteinase-8 Point-of-Care Oral Rinse Test.Journal of clinical periodontology · 2025Trial
- Efficacy and safety of a bioadhesive gel containing propolis extract, nanovitamin C and nanovitamin E on desquamative gingivitis: a double-blind, randomized, clinical trial.Clinical oral investigations · 2023Trial
- Salivary Cytokine Profiles in Active Smokers: An Exploratory Cross-Sectional Study of IL-2, IL-6, and IL-8.Diagnostics (Basel, Switzerland) · 2026Article
- Label-free, non-optical detection of intact SARS-CoV-2 virions in native human saliva via microscale surface ion conduction.Biosensors & bioelectronics · 2026Article
- Biomarkers for Treatment Response in Orthodontics: Molecular Mechanisms, Clinical Utility, and Future Directions.International journal of molecular sciences · 2026Review
- Baseline and treatment-induced change of salivary CYFRA 21 - 1 as independent predictors of recurrence in oral squamous cell carcinoma.Clinical oral investigations · 2026Article
- Local and General Inflammatory Mediators Status in Patients with Oral Lichen Planus.Biomedicines · 2026Article
- Dental Amalgam and Oral Biological Responses: A Narrative Review of Current Evidence.Dentistry journal · 2026Review
- Whole Transcriptomic Analysis Identifies Candidate Biomarkers from Saliva of Temporomandibular Joint Osteoarthritis Patients.International journal of molecular sciences · 2026Article
- Association of salivary proteins with periodontal disease in children and adolescents- a scoping review.BMC oral health · 2026Article
- Evaluation of salivary interleukin 6 interleukin 1 beta and interferon gamma in oral and mucocutaneous lichen planus patients.Scientific reports · 2026Article
- Beyond Oral Health: Personalized Strategies for Managing Oral Infections in Neutropenic Patients.Journal of personalized medicine · 2026Review
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saliva is a highly versatile biological fluid that is easy to gather in a non-invasive manner-and the results of its analysis complement clinical and histopathological findings in the diagnosis of multiple diseases. The objective of this review was to offer an update on the contribution of salivary biomarkers to the diagnosis and prognosis of diseases of the oral cavity, including oral lichen planus, periodontitis, Sjögren's syndrome, oral leukoplakia, peri-implantitis, and medication-related osteonecrosis of the jaw. Salivary biomarkers such as interleukins, growth factors, enzymes, and other biomolecules have proven useful in the diagnosis and follow-up of these diseases, facilitating the early evaluation of malignization risk and the monitoring of disease progression and response to treatment. However, further studies are required to identify new biomarkers and verify their reported role in the diagnosis and/or prognosis of oral diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.