ArticlePharmaceutics2020
Salt Cocrystal of Diclofenac Sodium-L-Proline: Structural, Pseudopolymorphism, and Pharmaceutics Performance Study.
Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Nano-cocrystals as Nanotechnology-based Approach to Modulate Solubility and Bioavailability of Poorly Soluble Drugs.Current topics in medicinal chemistry · 2026Review
- Structural, Spectroscopic, and Docking Analysis of N,O-Donor Ligand Metal Complex Nanoparticles With Hypolipidemic Effects via Lipoprotein Lipase Activation in High-Fat Diet Mice.Chemistry & biodiversity · 2025Article
- Development of a New Salt of Piperine with Toluene Sulfonic Acid and Its Anti-Inflammation Effect In Vivo.Molecules (Basel, Switzerland) · 2024Article
- Current Perspectives on Development and Applications of Cocrystals in the Pharmaceutical and Medical Domain.Cureus · 2024Review
- Article
- The Benefits and Challenges of Antibiotics-Non-Steroidal Anti-Inflammatory Drugs Non-Covalent Reaction.Molecules (Basel, Switzerland) · 2023Review
- Non-Covalent Reactions Supporting Antiviral Development.Molecules (Basel, Switzerland) · 2022Review
- Complexation: An Interesting Pathway for Combining Two APIs at the Solid State.Pharmaceutics · 2022Article
- New Organic Salt from Levofloxacin-Citric Acid: What Is the Impact on the Stability and Antibiotic Potency?Molecules (Basel, Switzerland) · 2022Article
- Structural Characterization of Multicomponent Crystals Formed from Diclofenac and Acridines.Materials (Basel, Switzerland) · 2022Article
- A Novel Carbon Dots/Thermo-Sensitive In Situ Gel for a Composite Ocular Drug Delivery System: Characterization, Ex-Vivo Imaging, and In Vivo Evaluation.International journal of molecular sciences · 2021Article
- Challenges and Progress in Nonsteroidal Anti-Inflammatory Drugs Co-Crystal Development.Molecules (Basel, Switzerland) · 2021Review
- Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review.Molecules (Basel, Switzerland) · 2021Review
- Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium.Materials (Basel, Switzerland) · 2021Article
- Improving the Solubility, Dissolution, and Bioavailability of Metronidazole via Cocrystallization with Ethyl Gallate.Pharmaceutics · 2021Article
- Cocrystal Applications in Drug Delivery.Pharmaceutics · 2020Article
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5 authors.
Funding
Abstract
Previously, we have reported on a zwitterionic cocrystal of diclofenac acid and L-proline. However, the solubility of this multicomponent crystal was still lower than that of diclofenac sodium salt. Therefore, this study aimed to observe whether a multicomponent crystal could be produced from diclofenac sodium hydrate with the same coformer, L-proline, which was expected to improve the pharmaceutics performance. Methods involved screening, solid phase characterization, structure determination, stability, and in vitro pharmaceutical performance tests. First, a phase diagram screen was carried out to identify the molar ratio of the multicomponent crystal formation. Next, the single crystals were prepared by slow evaporation under two conditions, which yielded two forms: one was a rod-shape and the second was a flat-square form. The characterization by infrared spectroscopy, thermal analysis, and diffractometry confirmed the formation of the new phases. Finally, structural determination using single crystal X-ray diffraction analysis solved the new salt cocrystals as a stable diclofenac-sodium-proline-water (1:1:1:4) named NDPT (natrium diclofenac proline tetrahydrate), and unstable diclofenac-sodium-proline-water (1:1:1:1), named NDPM (natrium diclofenac proline monohydrate). The solubility and dissolution rate of these multicomponent crystals were superior to those of diclofenac sodium alone. The experimental results that this salt cocrystal is suitable for further development.
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