Evidence map›Paper›PMID 32708312›Full record

ArticleInternational journal of molecular sciences2020

Different Mechanisms Underlie the Metabolic Response of GBM Stem-Like Cells to Ionizing Radiation: Biological and MRS Studies on Effects of Photons and Carbon Ions.

Alessandra Palma, Sveva Grande, Lucia Ricci-Vitiani, Anna Maria Luciani, Mariachiara Buccarelli, Mauro Biffoni, Valentina Dini, Giuseppe A P Cirrone, Mario Ciocca, Laura Guidoni and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Basic and translational research on carbon-ion radiobiology.American journal of cancer research · 2023
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Radiation Damage in Biomolecules and Cells.International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alessandra PalmaNational Centre for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Sveva GrandeNational Centre for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-1925-7602
Lucia Ricci-VitianiDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.
Anna Maria LucianiNational Centre for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Mariachiara BuccarelliDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-1157-4694
Mauro BiffoniDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.
Valentina DiniNational Centre for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-4125-0084
Giuseppe A P CirroneNational Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, 95123 Catania, Italy.
Mario CioccaCentro Nazionale di Adroterapia Oncologica (CNAO)-National Center for Oncological Hadrontherapy, 27100 Pavia, Italy.
Laura GuidoniNational Centre for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Roberto PalliniDepartment of Neuroscience, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Vincenza VitiNational Centre for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Antonella RosiNational Centre for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0001-8656-0671

Funding

Instituto Nazionale di Fisica Nucleare Gruppo V- Esperimento RADIOSTEM
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is a malignant primary brain tumor with very poor prognosis, high recurrence rate, and failure of chemo-radiotherapy, mainly due to a small fraction of cells with stem-like properties (GSCs). To study the mechanisms of GSCs resistance to radiation, two GSC lines, named line #1 and line #83, with different metabolic patterns and clinical outcome, were irradiated with photon beams and carbon ions and assessed by

Indexed as

Magnetic Resonance SpectroscopyBrain NeoplasmsCell Line, TumorG2 Phase Cell Cycle Checkpointsgamma-Aminobutyric AcidGlioblastomaGlucoseGlutamic AcidHumansIonsLactic AcidNeoplastic Stem CellsPhosphocreatinePhotonsRadiation, Ionizinggamma-Aminobutyric AcidGlucoseGlutamic AcidIonsLactic AcidPhosphocreatinecarbon ionsglioblastomametabolismMRSphoton beamsstem cells

Identifiers

PMID32708312
PMCPMC7404344

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.