Evidence map›Paper›PMID 32708306›Full record

ArticleInternational journal of molecular sciences2020

Dual Inhibition of CDK4/6 and PI3K/AKT/mTOR Signaling Impairs Energy Metabolism in MPM Cancer Cells.

Mara Bonelli, Rita Terenziani, Silvia Zoppi, Claudia Fumarola, Silvia La Monica, Daniele Cretella, Roberta Alfieri, Andrea Cavazzoni, Graziana Digiacomo, Maricla Galetti and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

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  17. Evaluation of tumour heterogeneity byBreast cancer research : BCR · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mara BonelliDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Rita TerenzianiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Silvia ZoppiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-8357-1073
Claudia FumarolaDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-3291-6668
Silvia La MonicaDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Daniele CretellaDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Roberta AlfieriDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0003-0601-7244
Andrea CavazzoniDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-3752-1868
Graziana DigiacomoDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Maricla GalettiINAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 00078 Monte Porzio Catone (Rome), Italy.ORCID 0000-0002-8061-8649
Pier Giorgio PetroniniDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
University of Parma · ITIstituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro · IT

Funding

Associazione Augusto per la Vita (Novellara, RE) N/AA.VO.PRO.RI.T. (Parma) N/ACHIESI Farmaceutici S.p.A. (Parma) N/AFamiglia Gigetto Furlotti (Parma) N/AFondazione CARIPARMA 2018.0184Ing. Marco Nocivelli, EPTA S.p.A (Milano) N/ATransfer Oil S.p.A. (Colorno, PR) N/A
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell Line, TumorCell ProliferationCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Energy MetabolismGlycolysisHumansMesothelioma, MalignantMitochondriaPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPiperazinesPleural NeoplasmsProtein Kinase InhibitorsProto-Oncogene Proteins c-aktPyridinesCDK4 protein, humanCDK6 protein, humanCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6MTOR protein, humanpalbociclibPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPiperazinesProtein Kinase InhibitorsProto-Oncogene Proteins c-aktPyridinesTOR Serine-Threonine KinasesCDK4/6 inhibitionmalignant pleural mesotheliomametabolismPalbociclibPI3K/mTOR inhibitors

Identifiers

PMID32708306
PMCPMC7403976
OpenAlexW3044480822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.