Evidence map›Paper›PMID 32708305›Full record

ArticleCancers2020

Natural Killer Cell Activation Receptor NKp30 Oligomerization Depends on Its

Ondřej Skořepa, Samuel Pazicky, Barbora Kalousková, Jan Bláha, Celeste Abreu, Tomáš Ječmen, Michal Rosůlek, Alexander Fish, Arthur Sedivy, Karl Harlos and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Protease-mediated maturation of M-PMV reverse transcriptase into a functional heterodimer.Protein science : a publication of the Protein Society · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. NKp30: A Key Membrane Molecule in the Fight Against Cancer and Infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. GANAB andInternational journal of molecular sciences · 2022
    Review
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Ondřej SkořepaDepartment of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 12840 Prague, Czech Republic.
Samuel PazickyDepartment of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 12840 Prague, Czech Republic.ORCID 0000-0002-4674-9784
Barbora KalouskováDepartment of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 12840 Prague, Czech Republic.ORCID 0000-0001-9048-3672
Jan BláhaDepartment of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 12840 Prague, Czech Republic.
Celeste AbreuDepartment of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 12840 Prague, Czech Republic.
Tomáš JečmenDepartment of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 12840 Prague, Czech Republic.ORCID 0000-0002-1137-9808
Michal RosůlekDepartment of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 12840 Prague, Czech Republic.ORCID 0000-0002-2426-7928
Alexander FishDepartment of Biochemistry, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Arthur SedivyProtein Technologies, Vienna Biocenter Core Facilities GmbH, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
Karl HarlosDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Jan DohnálekBIOCEV, Institute of Biotechnology, The Czech Academy of Sciences, Průmyslová 595, 25250 Vestec, Czech Republic.ORCID 0000-0002-8083-7980
Tereza SkálováBIOCEV, Institute of Biotechnology, The Czech Academy of Sciences, Průmyslová 595, 25250 Vestec, Czech Republic.ORCID 0000-0003-3186-2431
Ondřej VaněkDepartment of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 12840 Prague, Czech Republic.ORCID 0000-0003-1190-8535
Charles University · CZCzech Academy of Sciences, Institute of Biotechnology · CZCampus Science Support Facilities · ATCentre for Human Genetics · GBCzech Academy of Sciences · CZThe Netherlands Cancer Institute · NL

Funding

European Cooperation in Science and Technology CA15126European Regional Development Fund CZ.1.05/1.1.00/02.0109Grantová Agentura České Republiky 18-10687SGrantová Agentura, Univerzita Karlova 927916Ministerstvo Školství, Mládeže a Tělovýchovy CZ.02.1.01/0.0/0.0/16_013/0001776Ministerstvo Školství, Mládeže a Tělovýchovy LM2015043Ministerstvo Školství, Mládeže a Tělovýchovy LTC17065Univerzita Karlova v Praze SVV 260427/2020Wellcome Trust 203141/Z/16/Z
6 · The paper itself

Abstract

NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy. The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited. Moreover, ligand binding of NKp30 is affected by the presence and type of

Indexed as

B7-H6glycosylationNK cellNKp30oligomerization

Identifiers

PMID32708305
PMCPMC7409301
OpenAlexW3044139241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.