Evidence map›Paper›PMID 32708262›Full record

ArticleJournal of clinical medicine2020

Inhaled Dry Powder Antibiotics in Patients with Non-Cystic Fibrosis Bronchiectasis: Efficacy and Safety in a Real-Life Study.

Miguel Ángel Martínez-García, Grace Oscullo, Esther Barreiro, Selene Cuenca, Angela Cervera, Alicia Padilla-Galo, David de la Rosa, Annie Navarro, Rosa Giron, Francisco Carbonero and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Observational
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 1 country.

Miguel Ángel Martínez-GarcíaPneumology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.ORCID 0000-0002-7321-1891
Grace OsculloPneumology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.ORCID 0000-0002-2121-7554
Esther BarreiroCentro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Selene CuencaPneumology Department, Hospital General de Castellón, 12004 astelló, Spain.ORCID 0000-0002-5367-3335
Angela CerveraPneumology Department, Hospital General Universitario de Valencia, 46026 Valencia, Spain.ORCID 0000-0002-2422-0644
Alicia Padilla-GaloPneumology Department, Hospital Costa del Sol, 29604 Marbella, Spain.
David de la RosaPneumology Department, Hospital Universitario Santa Creu i Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0003-0753-1771
Annie NavarroPneumology Department, Hospital Universitario Mutua Terrassa, 08221 Barcelona, Spain.
Rosa GironPneumology Department, Hospital Univesitario la Princesa, 28006 Madrid, Spain.
Francisco CarboneroPneumology Department, Hospital de Jerez, 11407 Cádiz, Spain.
Maria Castro OteroPneumology Department, Hospital Central de la Defensa Gomez Ulla, 28028 Madrid, Spain.
Francisco CasasPneumology Department, Hospital Universitario San Cecilio, 18016 Granada, Spain.ORCID 0000-0002-8007-9323
Instituto de Salud Carlos III · ESHospital Central de la Defensa Gómez Ulla · ESHospital Costa del Sol · ESHospital de Sant Pau · ESHospital General Universitari de Castelló · ESHospital General Universitario De Valencia · ESHospital Jerez Puerta del Sur · ESHospital Universitari i Politècnic La Fe · ESHospital Universitario de La Princesa · ESInstituto de Investigación Biosanitaria de Granada · ESMútua Terrassa · ES

Funding

Sociedad Española de Neumologia SEPAR 010.2018
6 · The paper itself

Abstract

backgroundNebulised antibiotics are habitually used in patients with bronchiectasis, but the use of dry powder inhaled antibiotics (DPIA) in these patients is extremely limited. This study seeks to analyse the efficacy and safety of DPIA in bronchiectasis patients. MATERIAL AND

methodsMulti-centre study of historic cohorts. All the hospital centres in Spain were contacted in order to collect data on patients with a diagnosis of bronchiectasis who had taken at least one dose of DPIA. Its efficacy was analysed in clinical, functional and microbiological terms by comparing the year before and the year after the prescription of DPIA. Adverse effects and variables associated with these effects, or any need to withdraw the drug, were also analysed.

results164 patients from 33 Spanish centres were included; 86% and 14% of these were treated with dry powder colistin and tobramycin, respectively. Chronic bronchial infection by

conclusionsOur study suggests that DPIA are clinically efficacious and safe for treating bronchiectasis patients. Cough was shown to be the most common side-effect and reason for withdrawal of the treatment.

Indexed as

bronchiectasiscolistindry-powder antibioticsinhaled antibioticspseudomonas aeruginosatobramycin

Identifiers

PMID32708262
PMCPMC7408283
OpenAlexW3044908291

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.