ReviewJournal of clinical medicine2020
The Impact of the Extent of Surgery on the Long-Term Outcomes of Patients with Low-Risk Differentiated Non-Medullary Thyroid Cancer: A Systematic Meta-Analysis.
Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Recurrence risk of differentiated thyroid cancer treated with total or hemithyroidectomy: systematic review and meta-analysis.European thyroid journal · 2026Pooled it
- 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer.Thyroid : official journal of the American Thyroid Association · 2025Guideline
- FDG-PET/CT in indeterminate thyroid nodules: cost-utility analysis alongside a randomised controlled trial.European journal of nuclear medicine and molecular imaging · 2022Trial
- Article
- Preoperative and Intraoperative Assessment of Extrathyroidal Extension in Unilateral Papillary Thyroid Carcinoma: Does It Necessitate Total Thyroidectomy?Journal of surgical oncology · 2026Article
- Comparable long-term survival outcomes after lobectomy versus total thyroidectomy treatment of minimal extrathyroidal extension differentiated thyroid cancer patients.Gland surgery · 2026Article
- Pediatric thyroid cancer: a retrospective analysis of 42 cases.Frontiers in oncology · 2026Article
- Hemithyroidectomy versus total thyroidectomy for patients with differentiated thyroid cancer: a systematic review and meta-analysis.Gland surgery · 2025Article
- Postoperative Outcomes and Complication Profile Following Thyroidectomy: A Retrospective Analysis.Cureus · 2025Article
- Clinical efficacy of radioactive iodine therapy in multifocal papillary thyroid microcarcinoma: a tertiary center experience.Endocrine · 2025Article
- Impact of the 2015 American Thyroid Association Guidelines on Treatment of Low-Risk Thyroid Cancer.Laryngoscope investigative otolaryngology · 2025Article
- Postoperative complications and long-term outcomes after total and subtotal thyroidectomy: a retrospective study.Scientific reports · 2025Article
- MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer.European journal of nuclear medicine and molecular imaging · 2024Article
- Dynamic risk assessment in patients with differentiated thyroid cancer.Reviews in endocrine & metabolic disorders · 2024Review
- Bilaterality, not multifocality, is an independent risk factor for recurrence in low-risk papillary thyroid cancer.Journal of the National Cancer Institute · 2023Article
- Lobo-isthmectomy in the management of differentiated thyroid cancer.Thyroid research · 2023Review
- Thyroid Collision Tumors: The Presence of the Medullary Thyroid Carcinoma Component Negatively Influences the Prognosis.Diagnostics (Basel, Switzerland) · 2023Article
- Patient decision aids for patients with differentiated thyroid carcinoma: development process and alpha and beta testing.Frontiers in endocrinology · 2023Article
- Metformin Decreases Serum Thyroglobulin Concentration in Nonmedullary Thyroid Carcinoma.Journal of the Endocrine Society · 2022Article
- Thyroid lobectomy in patients with differentiated thyroid cancer: an analysis of the clinical outcomes in a nationwide multicenter study.Gland surgery · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
Abstract
Recently, the management of patients with low-risk differentiated non-medullary thyroid cancer (DTC), including papillary and follicular thyroid carcinoma subtypes, has been critically appraised, questioning whether these patients might be overtreated without a clear clinical benefit. The American Thyroid Association (ATA) guideline suggests that thyroid lobectomy (TL) could be a safe alternative for total thyroidectomy (TT) in patients with DTC up to 4 cm limited to the thyroid, without metastases. We conducted a meta-analysis to assess the clinical outcomes in patients with low-risk DTC based on the extent of surgery. The risk ratio (RR) of recurrence rate, overall survival (OS), disease-free survival (DFS) and disease specific survival (DSS) were estimated. In total 16 studies with 175,430 patients met the inclusion criteria. Overall, low recurrence rates were observed for both TL and TT groups (7 vs. 7%, RR 1.10, 95% CI 0.61-1.96,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.