Evidence map›Paper›PMID 32708213›Full record

ArticleCells2020

Hydrodynamics-Based Transplacental Delivery as a Useful Noninvasive Tool for Manipulating Fetal Genome.

Shingo Nakamura, Naoko Ando, Satoshi Watanabe, Eri Akasaka, Masayuki Ishihara, Masahiro Sato

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  2. Fetal gene therapy.Journal of inherited metabolic disease · 2024
    Review
  3. Perspectives in Genome-Editing Techniques for Livestock.Animals : an open access journal from MDPI · 2023
    Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Shingo NakamuraDivision of Biomedical Engineering, National Defense Medical College Research Institute, Saitama 359-8513, Japan.ORCID 0000-0001-6084-0958
Naoko AndoDivision of Biomedical Engineering, National Defense Medical College Research Institute, Saitama 359-8513, Japan.
Satoshi WatanabeAnimal Genome Unit, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki 305-0901, Japan.
Eri AkasakaSection of Gene Expression Regulation, Frontier Science Research Center, Kagoshima University, Kagoshima 890-8544, Japan.
Masayuki IshiharaDivision of Biomedical Engineering, National Defense Medical College Research Institute, Saitama 359-8513, Japan.
Masahiro SatoSection of Gene Expression Regulation, Frontier Science Research Center, Kagoshima University, Kagoshima 890-8544, Japan.ORCID 0000-0003-1334-2950
National Defense Medical College · JPKagoshima University · JPNational Agriculture and Food Research Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously demonstrated that the injection of pregnant wild-type female mice (carrying enhanced green fluorescent protein (EGFP)-expressing transgenic fetuses) at embryonic day (E) 12.5 with an all-in-one plasmid conferring the expression of both Cas9 and guide RNA (targeted to the

Indexed as

Gene Transfer TechniquesGenomeHydrodynamicsAnimalsBase SequenceFemaleFetusGene EditingMice, Inbred C57BLPlacentaPlasmidsPregnancyTime FactorscardiomyocytesCRISPR/Cas9fetal gene therapyfetusesgenome editinghydrodynamics-based gene delivery (HGD) systemmyosin heavy-chain αTPGD for acquiring genome-edited fetuses (TPGD-GEF)transplacental gene delivery (TPGD)

Identifiers

PMID32708213
PMCPMC7409276
OpenAlexW3044866635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.