Evidence map›Paper›PMID 32708145›Full record

ReviewGenes2020

The Role of BMI1 in Late-Onset Sporadic Alzheimer's Disease.

Ryan Hogan, Anthony Flamier, Eleonora Nardini, Gilbert Bernier

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Ryan HoganStem Cell and Developmental Biology Laboratory, Hôpital Maisonneuve-Rosemont, 5415 Boul. l'Assomption, Montreal, QC H1T 2M4, Canada.
Anthony FlamierWhitehead Institute of Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
Eleonora NardiniWhitehead Institute of Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
Gilbert BernierStem Cell and Developmental Biology Laboratory, Hôpital Maisonneuve-Rosemont, 5415 Boul. l'Assomption, Montreal, QC H1T 2M4, Canada.
Whitehead Institute for Biomedical Research · USHôpital Maisonneuve-Rosemont · CAUniversité de Montréal · CA

Funding

CIHR
6 · The paper itself

Abstract

Late-onset sporadic Alzheimer's disease (LOAD) seems to contain a "hidden" component that cannot be explained by classical Mendelian genetics, with advanced aging being the strongest risk factor. More surprisingly, whole genome sequencing analyses of early-onset sporadic Alzheimer's disease cohorts also revealed that most patients do not present classical disease-associated variants or mutations. In this short review, we propose that

Indexed as

Alzheimer DiseaseAnimalsEpigenesis, GeneticHumansMutationPolycomb Repressive Complex 1BMI1 protein, humanPolycomb Repressive Complex 1Alzheimer’s diseaseBMI1epigeneticslate-onsetsporadic

Identifiers

PMID32708145
PMCPMC7397074
OpenAlexW3045311409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.