Evidence map›Paper›PMID 32708088›Full record

ArticleCancers2020

The Biological Role of Sponge Circular RNAs in Gastric Cancer: Main Players or Coadjuvants?

Adenilson Leão Pereira, Leandro Magalhães, Rafael Pompeu Pantoja, Gilderlanio Araújo, Ândrea Ribeiro-Dos-Santos, Amanda Ferreira Vidal

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  19. You spin me right 'round.Neuro-oncology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Adenilson Leão PereiraFaculty of Medicine, Federal University of Pará, Altamira 68371-163, Brazil.ORCID 0000-0003-2687-5297
Leandro MagalhãesLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Graduate Program of Genetics and Molecular Biology, Federal University of Pará, Belém 66075-110, Brazil.
Rafael Pompeu PantojaLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Graduate Program of Genetics and Molecular Biology, Federal University of Pará, Belém 66075-110, Brazil.
Gilderlanio AraújoLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Graduate Program of Genetics and Molecular Biology, Federal University of Pará, Belém 66075-110, Brazil.
Ândrea Ribeiro-Dos-SantosResearch Center on Oncology, Graduate Program of Oncology and Medical Science, Federal University of Pará, Belém 66073-000, Brazil.
Amanda Ferreira VidalLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Graduate Program of Genetics and Molecular Biology, Federal University of Pará, Belém 66075-110, Brazil.ORCID 0000-0003-4180-9925
Universidade Federal do Pará · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq/Productivity: 304413/2015-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES/Biologia Computacional: No. 3381/2013/CAPESCoordenação de Aperfeiçoamento de Pessoal de Nível Superior Edital No.51/2013/Biologia Computacional; Proc. No. 88887.313819/2019-00/CAPES
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are a new class of long noncoding RNAs able to perform multiple functions, including sponging microRNAs (miRNAs) and RNA-Binding Proteins (RBPs). They play an important role in gastric carcinogenesis, but its involvement during gastric cancer (GC) development and progression are not well understood. We gathered miRNA and/or RBPs sponge circRNAs present in GC, and accessed their biological roles through functional enrichment of their target genes or ligand RBPs. We identified 54 sponge circRNAs in GC that are able to sponge 51 miRNAs and 103 RBPs. Then, we evaluated their host gene expression using The Cancer Genome Atlas (TCGA) database and observed that

Indexed as

circ_0000096circHIPK3circNF1circPVT1ciRS-7gastric carcinogenesisgastrointestinal tumorssponge circRNA

Identifiers

PMID32708088
PMCPMC7409348
OpenAlexW3045349070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.