ArticleInternational journal of molecular sciences2020
Preliminary In Vitro Evaluation of Chitosan-Graphene Oxide Scaffolds on Osteoblastic Adhesion, Proliferation, and Early Differentiation.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Fabrication and evaluation of PLA/CPP/GO composite scaffolds: the role of graphene oxide content in regulating properties.RSC advances · 2025Article
- Evaluating the potential of graphene oxide to promote skeletal muscle complex regeneration.Frontiers in bioengineering and biotechnology · 2025Article
- Surface Deformation of Biocompatible Materials: Recent Advances in Biological Applications.Biomimetics (Basel, Switzerland) · 2024Review
- Adhesive hydrogels in osteoarthritis: from design to application.Military Medical Research · 2023Review
- Role of chitosan in titanium coatings. trends and new generations of coatings.Frontiers in bioengineering and biotechnology · 2022Review
- Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective.Future science OA · 2022Review
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- Biomimetic Aspects of Oral and Dentofacial Regeneration.Biomimetics (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
An ideal scaffold should be biocompatible, having appropriate microstructure, excellent mechanical strength yet degrades. Chitosan exhibits most of these exceptional properties, but it is always associated with sub-optimal cytocompatibility. This study aimed to incorporate graphene oxide at wt % of 0, 2, 4, and 6 into chitosan matrix via direct blending of chitosan solution and graphene oxide, freezing, and freeze drying. Cell fixation, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, alkaline phosphatase colorimetric assays were conducted to assess cell adhesion, proliferation, and early differentiation of MG63 on chitosan-graphene oxide scaffolds respectively. The presence of alkaline phosphatase, an early osteoblast differentiation marker, was further detected in chitosan-graphene oxide scaffolds using western blot. These results strongly supported that chitosan scaffolds loaded with graphene oxide at 2 wt % mediated cell adhesion, proliferation, and early differentiation due to the presence of oxygen-containing functional groups of graphene oxide. Therefore, chitosan scaffolds loaded with graphene oxide at 2 wt % showed the potential to be developed into functional bone scaffolds.
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Registered trials
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