SynthesisNutrients2020
Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis.
Synthesis in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Vitamin D as a candidate host susceptibility factor in sugar-driven oral dysbiosis.Frontiers in oral health · 2026Pooled it
- Vitamin intake and periodontal disease: a meta-analysis of observational studies.BMC oral health · 2024Pooled it
- Association of vitamin D in individuals with periodontitis: an updated systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Dietary and Nutraceutical Interventions as an Adjunct to Non-Surgical Periodontal Therapy-A Systematic Review.Nutrients · 2023Pooled it
- Serum C-Reactive Protein and Periodontitis: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Evaluation of the effects of using an interdental brush dipped in 0.2% hyaluronic acid gel on clinical periodontal parameters among patients with periodontitis: a randomized controlled trial.BMC oral health · 2025Trial
- Serum vitamin D, hemoglobin A1c and vitamin B12 levels in patients with gingivitis and periodontitis stages.Biomarkers in medicine · 2024Trial
- The Effectiveness of Vitamin D Supplementation in Association with Non-Surgical Periodontal Therapy: A Systematic Review.Dentistry journal · 2026Review
- Periodontitis as a potential amplifier of diabetes-related genitourinary complications: evidence gradients and mechanistic insights into the inflammation-microvascular injury axis.Frontiers in cellular and infection microbiology · 2026Review
- Interaction between vitamin D insufficiency and periodontitis, GCF vitamin D and LL-37 levels in well-controlled diabetes patients with periodontitis.European oral research · 2026Article
- Vitamins in the Treatment of Periodontitis: Molecular Mechanism and Network Pharmacological Analysis.Oral health & preventive dentistry · 2025Review
- Impact of Adjunctive Air-Polishing on Periodontal Status in Patients with Low Vitamin DJournal of clinical medicine · 2025Article
- Does vitamin D levels influence the incidence of peri-implantitis? A systematic review of current evidence.The Saudi dental journal · 2025Review
- Association between vitamin D supplementation and the prevalence of dental caries and gingivitis in children. A cross-sectional study.Clinical oral investigations · 2025Article
- Association between vitamin K intake and periodontitis in American elderly population: a cross-sectional analysis of NHANES data.Clinical oral investigations · 2025Article
- Increasing Serum Vitamin D Levels Reduces Gingival Crevicular Fluid Matrix Metalloproteinase-9 Levels in Periodontal Health and Diseases.Journal of clinical periodontology · 2025Article
- Vitamin DInternational journal of molecular sciences · 2025Article
- Cross-sectional associations between vitamin D status and periodontitis in adults in Northern Norway: The Tromsø Study 2015-2016.BMC oral health · 2025Article
- The Influence of Diet and Physical Activity on Periodontal Health: A Narrative Review.Dentistry journal · 2025Review
- Effects of Vitamin D, Melatonin, and Omega-3 Fatty Acids on Periodontal Health: A Narrative Review.Dentistry journal · 2025Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the vitamin D levels of periodontitis patients in comparison with periodontally healthy ones, and to assess the influence of vitamin D supplementation as an adjunctive during nonsurgical periodontal treatment (NSPT). Five databases (Pubmed, Embase, Scholar, Web of Sciences, and Cochrane Library) were searched until May 2020. Mean difference (MD) meta-analysis with corresponding 95% confidence interval (95% CI) and sensitivity tests via meta-regression were used. We followed Strength of Recommendation Taxonomy (SORT) to appraise the strength and quality of the evidence. Sixteen articles were included, fourteen case-control and two intervention studies, all reporting 25-hydroxyvitamin D (25(OH)D) levels. Compared with the healthy controls, the circulating 25(OH)D levels were significantly lower in chronic periodontitis patients (pooled MD = -6.80, 95% CI: -10.59 to -3.02). Subgroup analysis revealed differences among 25(OH)D measurements, with liquid chromatography-mass spectrometry being the most homogeneous method (pooled MD = -2.05, 95% CI: -3.40 to -0.71). Salivary levels of 25(OH)D showed no differences between groups. Due to the low number of studies, conclusions on aggressive periodontitis and in the effect of vitamin D supplementation after NSPT were not possible to ascribe. Compared with healthy controls, 25(OH)D serum levels are significantly lower in chronic periodontitis patients, with an overall SORT A recommendation. Future studies are needed to clarify the effect of vitamin D supplementation and the biological mechanisms linking vitamin D to the periodontium.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.