ReviewNutrients2020
Persistent Iron Deficiency Anemia in Patients with Celiac Disease Despite a Gluten-Free Diet.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05172895 (Clinical Characteristics and Pathogenic Mechanisms of Anemia in Celiac Disease), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Characteristics and Pathogenic Mechanisms of Anemia in Celiac Disease
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Micronutrient deficiencies in patients with celiac disease: A systematic review and meta-analysis.International journal of immunopathology and pharmacologyPooled it
- Irregular follow-up is associated with poorer dietary adherence and iron deficiency in children with celiac disease.European journal of pediatrics · 2026Observational
- Serum Zonulin and Chitinase (CHI3L1) as Biomarkers of Intestinal Permeability and Disease Activity in Pediatric Celiac Disease.Children (Basel, Switzerland) · 2026Article
- Clinical and Histopathological Profile of Adults with Celiac Disease at Diagnosis and on a Gluten-Free Diet: A Cross-Sectional Observational Study.Clinics and practice · 2026Article
- Endocrine Autoimmunity and Inflammatory Signatures in Pediatric Celiac Disease: Context-Dependent Patterns.Diagnostics (Basel, Switzerland) · 2026Article
- Beyond the Follicle: A Narrative Review on How Systemic Diseases and Drugs Affect Alopecia.Pharmaceutical medicine · 2026Review
- Ironing Out the Deficiency: Tracking Iron in Celiac Disease Before and After the Gluten-Free Diet.Nutrients · 2026Review
- Narrative review of celiac disease and sports: nutritional deficiency and strategies to optimise athlete health and performance.Current research in food science · 2026Review
- The hidden link between iron deficiency and celiac disease: a clinical perspective.Frontiers in immunology · 2026Article
- Association of endocrine autoantibodies (anti-TPO, anti-GAD, anti-insulin) with histopathological severity in pediatric Celiac disease: a retrospective cohort study.BMC pediatrics · 2025Article
- Challenges in the Pediatric Celiac Disease Diagnosis: An Up-to-Date Review.Diagnostics (Basel, Switzerland) · 2025Review
- Celiac Disease Course of Eritrean Asylum-Seeker Children Living in Israel Compared to Native Israeli Children.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Long-term laboratory follow-up is essential in pediatric patients with celiac.Journal of pediatric gastroenterology and nutrition · 2025Article
- Intestinal fatty-acid binding protein as a diagnosis marker in younger with celiac diseases.Irish journal of medical science · 2025Article
- Persistence of anemia in patients with Celiac disease despite a gluten free diet: a retrospective study.BMC gastroenterology · 2025Article
- A gluten-free diet has a different effect on the iron profile of celiac disease and non-celiac gluten-sensitive patients with idiopathic iron deficiency anaemia.Gastroenterology and hepatology from bed to bench · 2025Article
- The Iron Enigma: Expounding Iron Deficiency in a Pregnant Woman With Hemochromatosis and Celiac Disease.Cureus · 2024Article
- Growth Stunting and Nutritional Deficiencies among Children and Adolescents with Celiac Disease in Kuwait: A Case-Control Study.Children (Basel, Switzerland) · 2024Article
- Iron deficiency and supplementation in heart failure.Nature reviews. Cardiology · 2024Review
- Vulnerability in Children with Celiac Disease: Findings from a Scoping Review.Children (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Celiac disease (CD) is an autoimmune disorder characterized by intolerance to dietary gluten in genetically predisposed subjects. Iron deficiency anemia (IDA) is a common sign in CD, being the only abnormality in approximately 40% of celiac patients. A multifactorial etiology leads to IDA in CD. The two main causes are the villous atrophy of the mucosa at the site of iron absorption (the duodenum) and the resulting inflammation, which triggers the mechanism that leads to the anemia of chronic disease. Until now, it has been unclear why some patients with CD continue to have IDA despite a careful gluten-free diet (GFD) and the normalization of villous atrophy. Furthermore, some celiac patients are refractory to oral iron supplementation despite the healing of the mucosa, and they thus require periodic intravenous iron administration. The Marsh classification evaluates the degree of inflammation and villous atrophy, but it does not assess the possible persistence of ultrastructural and molecular alterations in enterocytes. The latter was found in CD in remission after adopting a GFD and could be responsible for the persistently reduced absorption of iron and IDA. Even in non-celiac gluten sensitivity, anemia is present in 18.5-22% of patients and appears to be related to ultrastructural and molecular alterations in intestinal microvilli. It is possible that a genetic component may also play a role in IDA. In this review, we evaluate and discuss the main mechanisms of IDA in CD and the possible causes of its persistence after adopting a GFD, as well as their therapeutic implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.