Modulation of Glial Responses by Furanocembranolides: Leptolide Diminishes Microglial Inflammation in Vitro and Ameliorates Gliosis In Vivo in a Mouse Model of Obesity and Insulin Resistance.
Miriam Corraliza-Gómez, Amalia B Gallardo, Ana R Díaz-Marrero, José M de la Rosa, Luis D'Croz, José Darias, Eduardo Arranz, Irene Cózar-Castellano, María D Ganfornina, Mercedes Cueto
Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors at 3 institutions in 3 countries.
Miriam Corraliza-GómezInstituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC, 47003 Valladolid, Spain.
Amalia B GallardoInstituto de Productos Naturales y Agrobiología (IPNA-CSIC), Avenida Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Spain.
Ana R Díaz-MarreroInstituto de Productos Naturales y Agrobiología (IPNA-CSIC), Avenida Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Spain.ORCID 0000-0002-8886-7519
José M de la RosaInstituto de Productos Naturales y Agrobiología (IPNA-CSIC), Avenida Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Spain.
Luis D'CrozDepartamento de Biología Marina y Limnología, Universidad de Panamá, Panama 3366, Panama.
José DariasInstituto de Productos Naturales y Agrobiología (IPNA-CSIC), Avenida Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Spain.
Eduardo ArranzInstituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC, 47003 Valladolid, Spain.
Irene Cózar-CastellanoInstituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC, 47003 Valladolid, Spain.ORCID 0000-0002-6065-5362
María D GanforninaInstituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC, 47003 Valladolid, Spain.
Mercedes CuetoInstituto de Productos Naturales y Agrobiología (IPNA-CSIC), Avenida Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Spain.
Instituto de Productos Naturales y Agrobiología · ESUniversidad de Valladolid · ESUniversidad de Panamá · PA
Funding
Cabildo de Tenerife Agustín de Betancourt ProgrammeConsejería de Educación Junta Castilla y León VA086G18CSIC 2009CL0031Ministerio de Ciencia e Innovación BFU2015-68149-RMinisterio de Ciencia e Innovación RTA 2015-00010-C03-02Ministerio de Ciencia e Innovación SAF2016-77871-C2-1RUniversidad de Magallanes PR-F2-01-CRN18-19University of Valladolid Ph.D. fellowship call#2016
6 · The paper itself
Abstract
Neurodegenerative diseases are age-related disorders caused by progressive neuronal death in different regions of the nervous system. Neuroinflammation, modulated by glial cells, is a crucial event during the neurodegenerative process; consequently, there is an urgency to find new therapeutic products with anti-glioinflammatory properties. Five new furanocembranolides (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Modulation of Glial Responses by Furanocembranolides: Leptolide Diminishes Microglial Inflammation in Vitro and Ameliorates Gliosis In Vivo in a Mouse Model of Obesity and Insulin Resistance. · full record | OpenQuestion