ArticleAntibiotics (Basel, Switzerland)2020
Brazilian Red Propolis Is as Effective as Amoxicillin in Controlling Red-Complex of Multispecies Subgingival Mature Biofilm In Vitro.
Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Evaluation of the antimicrobial effect of cannabidiol (CBD) in a multispecies subgingival biofilm model.Journal of oral microbiology · 2026Article
- In vitro biomimetic development of artificial dental calculus: a proof of concept study.BMC oral health · 2025Article
- In-Vitro Effect of Manuka Honey / Propolis Toothpastes on Bacteria and Biofilm Associated with Caries and Gingivitis.Oral health & preventive dentistry · 2025Article
- Brazilian red propolis as a potential antimicrobial additive in orthodontic primers.Brazilian dental journal · 2025Article
- Propolis Use in Dentistry: A Narrative Review of Its Preventive and Therapeutic Applications.International dental journal · 2024Review
- Combination of Neovestitol and Vestitol Modifies the Profile of Periodontitis-Related Subgingival Multispecies Biofilm.Biomedicines · 2024Article
- Antibiofilm and Immune-Modulatory Activity of Cannabidiol and Cannabigerol in Oral Environments-In Vitro Study.Antibiotics (Basel, Switzerland) · 2024Article
- Propolis as a Cariostatic Agent in Lozenges and Impact of Storage Conditions on the Stability of Propolis.Pharmaceutics · 2023Article
- Case of Mixed Infection of Toenail Caused byJournal of fungi (Basel, Switzerland) · 2023Article
- Antimicrobial activity of Desplac® oral gel in the subgingival multispecies biofilm formation.Frontiers in microbiology · 2023Article
- Potential in vitro anti-periodontopathogenic, anti-Chikungunya activities and in vivo toxicity of Brazilian red propolis.Scientific reports · 2022Article
- In Vitro Study on Green Propolis as a Potential Ingredient of Oral Health Care Products.Antibiotics (Basel, Switzerland) · 2022Article
- Propolis, Aloe Vera, Green Tea, Cranberry, Calendula, Myrrha and Salvia Properties against Periodontal Microorganisms.Microorganisms · 2022Review
- Anti-Inflammatory Effects of (3Pharmaceuticals (Basel, Switzerland) · 2022Article
- Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies.Antioxidants (Basel, Switzerland) · 2022Review
- Natural products from traditional medicine as promising agents targeting at different stages of oral biofilm development.Frontiers in microbiology · 2022Review
- Classic vs. Novel Antibacterial Approaches for Eradicating Dental Biofilm as Adjunct to Periodontal Debridement: An Evidence-Based Overview.Antibiotics (Basel, Switzerland) · 2021Review
- In Vitro Activity of Propolis on Oral Microorganisms and Biofilms.Antibiotics (Basel, Switzerland) · 2021Article
- Antibacterial Activity of Propolis Extracts from the Central Region of Romania againstAntibiotics (Basel, Switzerland) · 2021Article
- Editorial for the Special Issue: "Honey Bee Products as an Alternative or Complement to Classical Antibiotics".Antibiotics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
This study investigated the effects of Brazilian Red Propolis (BRP) extract on seven-day-old multispecies subgingival biofilms. Mixed biofilm cultures containing 31 species associated with periodontal health or disease were grown for six days on a Calgary device. Then, mature biofilms were treated for 24 h with BRP extract at different concentrations (200-1600 µg/mL), amoxicillin (AMOXI) at 54 µg/mL (positive control) or vehicle (negative control). Biofilm metabolic activity was determined by colorimetry, and bacterial counts/proportions were determined by DNA-DNA hybridization. Data were analyzed by Kruskal-Wallis and Dunn's tests. Treatment with BRP at 1600, 800 and 400 μg/mL reduced biofilm metabolic activity by 56%, 56% and 57%, respectively, as compared to 65% reduction obtained with AMOXI. Mean total cell counts were significantly reduced in all test groups (~50-55%). Lower proportions of red, green and yellow complex species were observed upon treatment with BRP (400 µg/mL) and AMOXI, but only AMOXI reduced the proportions of
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.