ArticleInternational journal of molecular sciences2020
The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- Polydatin alleviates adenine-induced nephropathy in mice.Renal failure · 2026Article
- Targeting amino acid metabolic pathways: a novel therapeutic strategy for hyperuricemia-associated complications.Amino acids · 2026Review
- Sodium butyrate promotes synthesis of testosterone and meiosis of hyperuricemic male mice.Scientific reports · 2025Article
- Punicalagin attenuates hyperuricemia via restoring hyperuricemia-induced renal and intestinal dysfunctions.Journal of advanced research · 2025Article
- Quercetin ameliorates renal injury in hyperuricemic rats via modulating ER stress pathways.Frontiers in pharmacology · 2025Article
- Comparative analysis of hyperuricemia induction methods and probiotic interventions in mice.Current research in microbial sciences · 2025Article
- Causal effects of gut microbiota on gout and hyperuricemia: insights from genome-wide Mendelian randomization, RNA-sequencing, 16S rRNA sequencing, and metabolomes.Bioscience reports · 2024Article
- The pathogenic mechanism of monosodium urate crystal-induced kidney injury in a rat model.Frontiers in endocrinology · 2024Article
- Evaluating renal injury characteristics in different rat models of hyperuricemia and elucidating pathological molecular mechanisms via serum metabolomics.Frontiers in pharmacology · 2024Article
- Article
- New animal model of chronic gout reproduces pathological features of the disease in humans.RMD open · 2023Article
- Biodegradation of Inosine and Guanosine byInternational journal of molecular sciences · 2023Article
- Potential ProbioticMicroorganisms · 2022Article
- Risk factors and management of hyperuricemia after renal transplantation.Frontiers in surgery · 2022Review
- Function of Uric Acid Transporters and Their Inhibitors in Hyperuricaemia.Frontiers in pharmacology · 2021Article
- Drug Transporters in the Kidney: Perspectives on Species Differences, Disease Status, and Molecular Docking.Frontiers in pharmacology · 2021Review
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
Hyperuricemia is an important risk factor of chronic kidney disease, metabolic syndrome and cardiovascular disease. We aimed to assess the time-feature relationship of hyperuricemia mouse model on uric acid excretion and renal function. A hyperuricemia mouse model was established by potassium oxonate (PO) and adenine for 21 days. Ultra Performance Liquid Chromatography was used to determine plasma uric acid level. Hematoxylin-eosin staining was applied to observe kidney pathological changes, and Western blot was used to detect renal urate transporters' expression. In hyperuricemia mice, plasma uric acid level increased significantly from the 3rd day, and tended to be stable from the 7th day, and the clearance rate of uric acid decreased greatly from the 3rd day. Further study found that the renal organ of hyperuricemia mice showed slight damage from the 3rd day, and significantly deteriorated renal function from the 10th day. In addition, the expression levels of GLUT9 and URAT1 were upregulated from the 3rd day, while ABCG2 and OAT1 were downregulated from the 3rd day, and NPT1 were downregulated from the 7th day in hyperuricemia mice kidney. This paper presents a method suitable for experimental hyperuricemia mouse model, and shows the time-feature of each index in a hyperuricemia mice model.
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