Evidence map›Paper›PMID 32707726›Full record

ArticleNutrients2020

Serum Scoring and Quantitative Magnetic Resonance Imaging in Intestinal Failure-Associated Liver Disease: A Feasibility Study.

Konstantinos C Fragkos, María Claudia Picasso Bouroncle, Shankar Kumar, Lucy Caselton, Alex Menys, Alan Bainbridge, Stuart A Taylor, Francisco Torrealdea, Tomoko Kumagai, Simona Di Caro and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Konstantinos C FragkosIntestinal Failure Service, Gastrointestinal Services, University College London Hospitals NHS Foundation Trust, London NW1 2BU, UK.ORCID 0000-0002-7677-7989
María Claudia Picasso BouroncleIntestinal Failure Service, Gastrointestinal Services, University College London Hospitals NHS Foundation Trust, London NW1 2BU, UK.
Shankar KumarUCL Centre for Medical Imaging, University College London, London WC1E 6BT, UK.
Lucy CaseltonUCL Centre for Medical Imaging, University College London, London WC1E 6BT, UK.
Alex MenysUCL Centre for Medical Imaging, University College London, London WC1E 6BT, UK.
Alan BainbridgeDepartment of Medical Physics, University College London Hospitals NHS Foundation Trust, London WC1N 3BG, UK.
Stuart A TaylorUCL Centre for Medical Imaging, University College London, London WC1E 6BT, UK.
Francisco TorrealdeaDepartment of Medical Physics, University College London Hospitals NHS Foundation Trust, London WC1N 3BG, UK.
Tomoko KumagaiUCL Division of Medicine, University College London, London WC1E 6BT, UK.
Simona Di CaroIntestinal Failure Service, Gastrointestinal Services, University College London Hospitals NHS Foundation Trust, London NW1 2BU, UK.
Farooq RahmanIntestinal Failure Service, Gastrointestinal Services, University College London Hospitals NHS Foundation Trust, London NW1 2BU, UK.
Jane MacnaughtanUCL Institute for Liver and Digestive Health, University College London, London WC1E 6BT, UK.ORCID 0000-0003-1211-9298
Manil D ChouhanUCL Centre for Medical Imaging, University College London, London WC1E 6BT, UK.ORCID 0000-0001-5903-1002
Shameer MehtaIntestinal Failure Service, Gastrointestinal Services, University College London Hospitals NHS Foundation Trust, London NW1 2BU, UK.ORCID 0000-0002-7002-293X
University College London · GBUniversity College London Hospitals NHS Foundation Trust · GB

Funding

Medical Research Council MR/R001901/1UCLH Biomedical Research Centre //
6 · The paper itself

Abstract

(1) Background: Intestinal failure-associated liver disease (IFALD) in adults is characterized by steatosis with variable progression to fibrosis/cirrhosis. Reference standard liver biopsy is not feasible for all patients, but non-invasive serological and quantitative MRI markers for diagnosis/monitoring have not been previously validated. Here, we examine the potential of serum scores and feasibility of quantitative MRI used in non-IFALD liver diseases for the diagnosis of IFALD steatosis; (2) Methods: Clinical and biochemical parameters were used to calculate serum scores in patients on home parenteral nutrition (HPN) with/without IFALD steatosis. A sub-group underwent multiparameter quantitative MRI measurements of liver fat fraction, iron content, tissue T1, liver blood flow and small bowel motility; (3) Results: Compared to non-IFALD (

Indexed as

Magnetic Resonance ImagingAdipose TissueAdultAgedAspartate AminotransferasesBiomarkersCohort StudiesCross-Sectional StudiesFatty LiverFeasibility StudiesFemalegamma-GlutamyltransferaseHumansIntestinal DiseasesLiverMaleAspartate AminotransferasesBiomarkersgamma-Glutamyltransferasefibrosis scoresintestinal failureintestinal failure associated liver diseaseliver diseasemagnetic resonance imagingparenteral nutrition

Identifiers

PMID32707726
PMCPMC7400956
OpenAlexW3043142426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.