Evidence map›Paper›PMID 32707682›Full record

ArticleInternational journal of environmental research and public health2020

Short-Term ONX-0914 Administration: Performance and Muscle Phenotype in

Dongmin Kwak, Guoxian Wei, LaDora V Thompson, Jong-Hee Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Dongmin KwakDepartment of Physical Therapy and Athletic Training, Boston University, Boston, MA 02215, USA.
Guoxian WeiDepartment of Physical Therapy and Athletic Training, Boston University, Boston, MA 02215, USA.ORCID 0000-0001-5115-3697
LaDora V ThompsonDepartment of Physical Therapy and Athletic Training, Boston University, Boston, MA 02215, USA.
Jong-Hee KimDepartment of Physical Education, Hanyang University, Seoul 04763, Korea.
Boston University · USHanyang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease. Although the lack of dystrophin protein is the primary defect responsible for the development of DMD, secondary disease complications such as persistent inflammation contribute greatly to the pathogenesis and the time-dependent progression of muscle destruction. The immunoproteasome is a potential therapeutic target for conditions or diseases mechanistically linked to inflammation. In this study, we explored the possible effects of ONX-0914 administration, an inhibitor specific for the immunoproteasome subunit LMP7 (ß5i), on motor performance, muscular pathology and protein degradation in 7-week old

Indexed as

DystrophinMuscle, SkeletalOligopeptidesAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, Inbred mdxMuscular Dystrophy, DuchennePhenotypeYoung AdultDystrophinOligopeptidesPR-9577-week old Mdx miceDuchenne muscular dystrophyimmunoproteasomeinflammationLMP7motor performanceONX-0914

Identifiers

PMID32707682
PMCPMC7399807
OpenAlexW3042356727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.