Evidence map›Paper›PMID 32707596›Full record

ArticleCell proliferation2020

Ligand-targeted polymerase chain reaction for the detection of folate receptor-positive circulating tumour cells as a potential diagnostic biomarker for pancreatic cancer.

Hao Cheng, Wei He, Jun Yang, Qing Ye, Lu Cheng, Yiming Pan, Liang Mao, Xuehui Chu, Chenglin Lu, Gang Li and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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  10. Tumor biomarkers for diagnosis, prognosis and targeted therapy.Signal transduction and targeted therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Hao ChengNanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0001-6621-7614
Wei HeDepartment of Medicine, Geno Biotech Co Ltd, Shanghai, China.
Jun YangDepartment of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Qing YeDepartment of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Lu ChengDepartment of Research and Development, Geno Biotech Co Ltd, Shanghai, China.
Yiming PanDepartment of Hepatobiliary and Pancreatic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Liang MaoDepartment of Hepatobiliary and Pancreatic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Xuehui ChuDepartment of Hepatobiliary and Pancreatic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Chenglin LuDepartment of Hepatobiliary and Pancreatic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Gang LiDepartment of Hepatobiliary and Pancreatic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Yudong QiuNanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Jian HeDepartment of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Nanjing Drum Tower Hospital · CN

Funding

Key Medical Talents Program of Jiangsu Province ZDRCA2016057
6 · The paper itself

Abstract

objectivesTo detect folate receptor (FR)-positive circulating tumour cells (FR MATERIALS AND

methodsCTCs were enriched from 3 mL of peripheral blood and portal vein blood by immunomagnetic depletion of leucocytes and were then detected by LT-PCR. The diagnostic performance of FR

resultsIn total, 57 consecutive patients, including 46 patients with PC, five patients with non-pancreatic periampullary cancer (non-PC) and six patients with benign pancreatic diseases, were enrolled. FR

conclusionsLT-PCR is feasible and reliable for detecting FR

Indexed as

AdultAgedAged, 80 and overAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorFemaleFolate Receptors, GPI-AnchoredHumansMaleMiddle AgedNeoplastic Cells, CirculatingPancreatic NeoplasmsPolymerase Chain ReactionAntigens, Tumor-Associated, CarbohydrateBiomarkers, Tumorcarbohydrate antigen 199, humanFolate Receptors, GPI-Anchoredcirculating tumour cellsfolate receptorligand-targeted polymerase chain reactionpancreatic cancerperiampullary cancer

Identifiers

PMID32707596
PMCPMC7507398
OpenAlexW3045331540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.